中风与神经疾病杂志2025，Vol.42Issue(12)：1100-1110,11.DOI:10.19845/j.cnki.zfysjjbzz.2025.0200
遗传相关性、双向双样本孟德尔随机化分析失眠与焦虑症的关系
Association between insomnia and anxiety:An analysis based on genetic correlation and bidirectional two-sample Mendelian randomization
摘要
Abstract
Objective To investigate the potential genetic mechanisms of insomnia and anxiety and the bidirec-tional causal relationship between them using Linkage Disequilibrium Score Regression(LDSC)and Mendelian Random-ization(MR).Methods Based on the data from genome-wide association studies,LDSC was used to analyze the genetic correlation of insomnia with anxiety and its subtypes.The inverse variance weighted(IVW)method was used as the main analytical method,supplemented by MR-Egger regression,weighted median,the simple model method,and weighted model.The Cochran's Q test was used for heterogeneity testing,MR-Egger was used for pleiotropy testing,and the leave-one-out method was used for sensitivity analysis.Results The LDSC analysis revealed the genetic correlation of insomnia with anxiety and its subtypes.The results of IVW analysis showed that insomnia had a causal relationship with the in-creased risk of anxiety(OR=1.448,95%CI 1.025‒2.045,P=0.036,PFDR=0.178)and generalized anxiety disorder(OR=2.098,95%CI 1.105‒3.986,P=0.024,PFDR=0.314).Conversely,the reverse MR analysis showed a causal relationship be-tween generalized anxiety disorder and the increased risk of insomnia(OR=1.010,95%CI 1.003‒1.017,P=0.008,PFDR=0.329).No significant horizontal pleiotropy was detected for the instrumental variables(P>0.05),and the sensitivity analysis showed that the results of MR analysis were stable.Conclusion Insomnia may be used as a risk factor for anxiety,and there is a genetic correlation between the two diseases.关键词
失眠/焦虑症/孟德尔随机化/因果关系/连锁不平衡回归分析Key words
Insomnia/Anxiety/Mendelian randomization/Causal relationship/Linkage Disequilibrium Score Regression分类
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林志烽,董孟龙,宿长军,赵显超,王怡,杨倚清,吴琪,程金湘..遗传相关性、双向双样本孟德尔随机化分析失眠与焦虑症的关系[J].中风与神经疾病杂志,2025,42(12):1100-1110,11.基金项目
国家重点研发计划"常见多发病防治研究"重点专项(2021YFC2501400) （2021YFC2501400）
国家自然科学基金青年项目(82200103) （82200103）
