中风与神经疾病杂志2025，Vol.42Issue(12)：1111-1118,8.DOI:10.19845/j.cnki.zfysjjbzz.2025.0201
亲环蛋白A、亲环蛋白D与急性缺血性脑卒中预后的相关性研究
Correlation of cyclophilin A and cyclophilin D with the prognosis of acute ischemic stroke
摘要
Abstract
Objective To investigate the correlation of the expression levels of serum cyclophilin A(CyPA)and cy-clophilin D(CyPD)with the prognosis of patients with acute ischemic stroke(AIS).Methods A total of 170 patients with first-episode AIS who attended Department of Neurology,The First Affiliated Hospital of Shihezi University,from Oc-tober 2023 to June 2024 were enrolled as AIS group,and 60 non-AIS patients who were admitted during the same period of time were enrolled as control group.Clinical data were collected,and ELISA was used to measure the serum levels of CyPA and CyPD.For AIS patients,National Institutes of Health Stroke Scale(NIHSS)score and modified Rankin Scale(mRS)score were used to assess neurological deficits on admission and on day 90 after onset;the Fatigue,Resistance,Ambulation,Illnesses,and Loss of Weight(FRAIL)scale was used to evaluate the status of frailty;the multivariate logis-tic regression analysis was used to explore the correlation of the serum levels of CyPA and CyPD with neurological dysfunc-tion at 3 months after the onset of AIS.The receiver operating characteristic(ROC)curve was used to assess the value of the serum levels of CyPA and CyPD in predicting neurological dysfunction in AIS patients at 3 months.Results The AIS group had significantly higher serum levels of CyPA and CyPD than the control group(P<0.001).The Spearman correla-tion analysis showed that the expression levels of serum CyPA and CyPD were significantly positively correlated with NIHSS score(P<0.001).The multivariate logistic regression analysis showed that the expression levels of serum CyPA and CyPD were independent influencing factors for neurological deterioration at 3 months after the onset of AIS(P<0.05).The ROC curve analysis showed that serum CyPA and CyPD used alone or in combination had an area under the ROC curve of 0.875(95%CI 0.824‒0.926,P<0.001),0.790(95%CI 0.718‒0.862,P<0.001),and 0.898(95%CI 0.851‒0.944,P<0.001),re-spectively,in predicting short-term adverse prognosis in AIS patients.Conclusion Serum CyPA and CyPD are independent influencing factors for the prognosis of AIS,and their combination has a certain value in pre-dicting the prognosis of AIS.关键词
急性缺血性脑卒中/血清亲环蛋白A/血清亲环蛋白D/预后Key words
Acute ischemic stroke/Serum cyclophilin A/Serum cyclophilin D/Prognosis分类
医药卫生引用本文复制引用
高沛沛,唐娟,余鹃,魏磊国,王娟娟,张旭,田苗苗,苏李涵,姚恩生..亲环蛋白A、亲环蛋白D与急性缺血性脑卒中预后的相关性研究[J].中风与神经疾病杂志,2025,42(12):1111-1118,8.基金项目
国家卫生健康委医药卫生科技发展科技中心(WKZX2023CZ0126) （WKZX2023CZ0126）
兵团指导性科技计划项目(2022ZD072) （2022ZD072）
八师石河子市科技计划项目(2023BX01-3) （2023BX01-3）
"天山英才"医药卫生高层次人才培养计划 （）
非传染性慢性病国家科技重大专项(2024ZD0527700) （2024ZD0527700）
