中国病理生理杂志2025，Vol.41Issue(12)：2465-2472,8.DOI:10.3969/j.issn.1000-4718.2025.12.022
运动调控Nrf2/BDNF信号通路抑制铁死亡在帕金森病中的潜在机制
Mechanisms underlying exercise-induced inhibition of ferroptosis in par-kinson disease via Nrf2/BDNF pathway
摘要
Abstract
Parkinson disease(PD)is a prevalent neurodegenerative disorder,clinically characterized by symptoms such as muscle rigidity,resting tremor,and bradykinesia.Recent studies have indicated that ferroptosis,a new-ly identified form of cell death,may play a critical role in the pathogenesis of PD.This process is initiated by disorders in iron metabolism and oxidative stress,which ultimately lead to neuronal dysfunction.Exercise,recognized as a safe and ef-fective non-pharmacological intervention,has the potential to activate the nuclear factor E2-related factor 2(Nrf2)/brain-derived neurotrophic factor(BDNF)signaling pathway,enhance antioxidant capacity,and regulate iron metabolism.These effects collectively inhibit the onset of ferroptosis and improve neuronal function.This article systematically reviews the mechanisms of ferroptosis in PD and discusses in detail how exercise may regulate ferroptosis through the Nrf2/BDNF pathway.The aim is to provide a new theoretical framework and clinical intervention strategies for the prevention and treat-ment of PD.关键词
运动/铁死亡/帕金森病/Nrf2/BDNF信号通路Key words
exercise/ferroptosis/Parkinson disease/Nrf2/BDNF signaling pathway分类
医药卫生引用本文复制引用
卢冬磊,曹立全,谭思洁..运动调控Nrf2/BDNF信号通路抑制铁死亡在帕金森病中的潜在机制[J].中国病理生理杂志,2025,41(12):2465-2472,8.基金项目
科技部国家重点研发计划(No.2020YFC2006704) （No.2020YFC2006704）
