中风与神经疾病杂志2025，Vol.42Issue(12)：1119-1125,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0202
线粒体脑肌病伴高乳酸血症和卒中样发作的脑电图特征
Electroencephalographic characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
摘要
Abstract
Objective To investigate the electroencephalographic(EEG)manifestations of children with mitochon-drial encephalomyopathy with lactic acidosis and stroke-like episodes(MELAS),to explore the EEG characteristics of such patients and their correlation with neuroimaging findings,and to provide a reference for the early clinical diagnosis of MELAS.Methods A retrospective analysis was performed for the EEG and neuroimaging data of 11 children who were admitted to Department of Pediatric Neurology,The First Hospital of Jilin University,from January 2016 to December 2024 and were diagnosed with MELAS by genetic testing.Results There were varying degrees of EEG background abnor-malities in the children with MELAS.Interictal epileptiform discharges predominantly involved the posterior head region.Seizures mainly manifested as focal seizures,frequently originating from the posterior head regions.Serial EEG and neuro-imaging examinations showed changes in lesion sites over time,with consistent localization of lesions in more than half of the cases based on the two examinations,predominantly involving the posterior head regions.Conclusion In clinical practice,most children with MELAS have the initial manifestation of seizures,and the possibility of MELAS should be considered in case of the characteristic changes in EEG and imaging examinations,so as to provide help for early identifi-cation and diagnosis.关键词
线粒体脑肌病/脑电图/癫痫/磁共振成像/儿童Key words
Mitochondrial encephalopathy/Electroencephalography/Epilepsy/Magnetic resonance imaging/Child分类
医药卫生引用本文复制引用
孙万庆,张艳凤,李文涛,王艺竹,陈丽敏,王江涛,梁建民..线粒体脑肌病伴高乳酸血症和卒中样发作的脑电图特征[J].中风与神经疾病杂志,2025,42(12):1119-1125,7.基金项目
吉林省卫生健康科技能力提升项目(2022LC102) （2022LC102）
国家自然科学基金面上项目(82271509和81771396) （82271509和81771396）
吉林省儿科神经重点实验室项目(YDZJ202102CXJD021) （YDZJ202102CXJD021）
吉林省科技发展计划项目(YDZJ202201ZYTS676) （YDZJ202201ZYTS676）
吉林省医疗卫生人才专项(JLSWSRCZX2021053) （JLSWSRCZX2021053）
