中风与神经疾病杂志2025，Vol.42Issue(12)：1145-1149,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0207
中枢性位置性眼震的研究进展
Research advances in central positional nystagmus
摘要
Abstract
Central positional nystagmus(CPN)is a form of positional nystagmus caused by lesions of the central vestibular system.Since the clinical manifestations and nystagmus features of CPN are highly similar with those of benign paroxysmal positional vertigo,the diagnosis of CPN is highly challenging.The etiology of CPN is complex,involving both structural lesions such as stroke and tumors and non-structural disorders such as vestibular migraine.The primary lesion sites of CPN included the cerebellar nodulus,the uvula,and the tonsil.CPN can be classified into paroxysmal(transient)CPN and persistent CPN.The clinical features of paroxysmal CPN(including latency,duration,direction,intensity,and their correlation with the type and speed of positional maneuvers)suggest that it originates from the semicircular canal,and its pathogenesis involves post-rotatory rebound nystagmus caused by the disinhibition of irregular afferent signals trans-mitted to the vestibular nuclei due to central damage(often involving the cerebellar nodulus and the uvula).Persistent CPN may be caused by damage to the velocity storage pathway,resulting in an erroneous assessment of gravity direction and inertia.This article summarizes the latest advances in the etiology,lesion sites,pathogenesis,clinical features,dif-ferential diagnosis,and treatment of CPN in China and globally,in order to help clinicians better understand and identify CPN and thus achieve timely diagnosis and effective treatment.关键词
中枢性位置性眼震/小脑小结叶/小脑蚓垂/小脑扁桃体/速度储存机制Key words
Central positional nystagmus/Cerebellar nodulus/Uvula/Tonsil/Velocity storage mechanism分类
医药卫生引用本文复制引用
凌霞,吴月霞,薛思儒,李康之,王阳,杨旭,王朝霞..中枢性位置性眼震的研究进展[J].中风与神经疾病杂志,2025,42(12):1145-1149,5.基金项目
北京大学第一医院科研种子基金(2023SF14) （2023SF14）
