药食同源杂志2025，Vol.1Issue(7)：1-10,10.
中药治疗新型冠状病毒感染的真实世界研究、用药规律及药食同源产品开发
Real-world study on Chinese medicine for COVID-19:Efficacy,medication patterns,and development of medicine-food homologous products
摘要
Abstract
Objective To evaluate the efficacy of Chinese medicine(CM)interventions for coronavirus disease 2019(COVID-19)in Hunan Province,identify core medicinal combinations,and provide a data foundation for developing medicine-food homologous products for the full-cycle intervention of COVID-19.Methods Moderate cases of COVID-19 treated at four large tertiary hospitals in Hunan Province were collected.Based on the presence or absence of CM treatment,the patients were divided into a non-CM treatment group and a CM treatment group for prognosis comparison.For the CM treatment group,SPSS 26.0 was used to conduct frequency analysis,frequent itemset mining,and association rule visualization of the prescribed medicines,aiming to identify effective prescriptions.Results At discharge,the effective rate was 95.09%(2713/2853)in the non-CM treatment group and 94.50%(1151/1218)in the CM treatment group,with no statistically significant difference between the two groups(P>0.05).The CM treatment group effectively reduced the length of hospital stay(P<0.05)and significantly lowered the rate of progression to severe disease(P<0.01).Analysis of medication patterns identified the high-frequency herbs as Fuling(Poria)(532 times),Fabanxia(Pinelliae Rhizoma Praeparatum)(490 times),and Chenpi(Citri Reticulatae Pericarpium)(428 times).The core medicinal combinations were Chenpi(Citri Reticulatae Pericarpium)+Fabanxia(Pinelliae Rhizoma Praeparatum),Fuling(Poria)+Fabanxia(Pinelliae Rhizoma Praeparatum),and Fuling(Poria)+Chenpi(Citri Reticulatae Pericarpium),which constitute the core components of the classical formula Erchen Decoction.Conclusion The application of Chinese medicine can shorten the course of COVID-19 and promote patient recovery.Integrating the identified core medicinal combinations with the theory of medicine and food homology to develop Chinese herbal teas holds significant theoretical and clinical value.This approach is particularly meaningful for restoring lung and spleen function and eliminating residual pathological factors(e.g.,phlegm-dampness)in patients recovering from COVID-19.关键词
COVID-19/药食同源/真实世界研究/用药规律/二陈汤Key words
COVID-19/medicine and food homology/real-world study/medication pattern/Erchen Decoction分类
医药卫生引用本文复制引用
刘慧,姚舒涵,戴爱国,肖俐敏,王娟,易健,丁蓉珍,彭敏恋,游柏稳,游舒颖,毕淑敏..中药治疗新型冠状病毒感染的真实世界研究、用药规律及药食同源产品开发[J].药食同源杂志,2025,1(7):1-10,10.基金项目
2023年湖南省新冠病毒感染疾病科研攻关项目(2023SK2002) （2023SK2002）
2023年度国家自然科学基金项目(82370069) （82370069）
2023年度湖南中医药大学粉体与创新药物省部共建国家重点实验室培育基地开发基金重点资助项目(23PTKF1007) （23PTKF1007）
2025年度湖南省自然科学高校联合基金重点项目(2025JJ90008). （2025JJ90008）
