中国临床心理学杂志2025，Vol.33Issue(6)：1130-1135,6.DOI:10.16128/j.cnki.1005-3611.2025.06.002
青少年抑郁症患者静息态fNIRS功能连接特征与认知功能的相关性分析
Resting-state fNIRS Functional Connectivity of the Prefrontal Cortex and Its Association with Cognitive Function in Adolescents with Major Depressive Disorder
摘要
Abstract
Objective:To investigate the characteristics of resting-state functional connectivity(FC)in adolescents with major depressive disorder(aMDD)using functional near-infrared spectroscopy(fNIRS),and their associations with cogni-tive performance.Methods:Forty adolescents with MDD and 57 age-and sex-matched healthy controls were enrolled.Resting-state fNIRS data were collected to assess FC.Cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results:Compared to the HC group:(1)the aMDD group showed sig-nificantly increased FC between several prefrontal regions among the right and left dorsolateral prefrontal cortex(DLPFC),right frontal eye field(FEF),and right frontopolar area(P＜0.05);(2)the aMDD group exhibited significantly lower RBANS total and subscale scores across all domains(P＜0.05);(3)RBANS cognitive scores were negatively correlated with FC within prefrontal regions.Specifically,right FEF-right DLPFC FC was negatively correlated with delayed memory(r=-0.208,P=0.042);right DLPFC-right FPA FC was negatively correlated with immediate memory(r=-0.227,P=0.026),at-tention(r=-0.214,P=0.036),and total RBANS score(r=-0.233,P=0.022).Conclusion:aMDD is characterized by prefron-tal hyperconnectivity and cognitive impairment.Excessive synchronization within the prefrontal network may underlie cogni-tive deficits.关键词
青少年抑郁症/功能性近红外光谱成像/认知功能/前额叶/功能连接Key words
Adolescent depression/Functional near-infrared spectroscopy/Cognitive function/Prefrontal cortex/Func-tional connectivity分类
医药卫生引用本文复制引用
卢佳仪,冯可,廖传馨,范天晴,刘驿,申艳梅..青少年抑郁症患者静息态fNIRS功能连接特征与认知功能的相关性分析[J].中国临床心理学杂志,2025,33(6):1130-1135,6.基金项目
国家自然科学基金(82201703 （）
82571762). （）
