中国全科医学2026，Vol.29Issue(5)：612-622,11.DOI:10.12114/j.issn.1007-9572.2024.0327
肠道微生物群对代谢综合征的遗传预测因果效应研究
A Study of the Causal Effect of Gut Microbiota on Genetic Prediction of Metabolic Syndrome
摘要
Abstract
Background Many observational studies have found an association between the gut microbiome and metabolic syndrome(MetS)and its components,but the causal relationship between them is not yet clear.Objective To explore a bidirectional causal relationship between the gut microbiota and the MetS and its components.Methods This study obtained gut microbiota-associated single nucleotide polymorphisms from MiBioGen,obtained summary statistics of MetS and its components in the UK Biobank,Complex Trait Genetics(CTG),and other consortiums studies,and performed bidirectional two-sample Mendelian randomization analyses to assess the relationship between causal relationships.In addition,a series of sensitivity analyses were performed to verify the robustness of the Mendelian randomization analysis results.To obtain a more rigorous causal interpretation,Bonferroni correction was used to test the strength of the causal relationship between gut microbiota and MetS.Results Inverse variance weighted estimation showed that Bifidobacteriaceae(OR=0.96,95%CI=0.93-0.98,P=1.49×10-3)had a significant negative causal relationship with MetS.There was a significant positive causal relationship between some gut microbiota and waist circumference,such as class.Melainabacteria(OR=1.02,95%CI=1.01-1.03,P=1.90×10-3),order.Gastranaerophilales(OR=1.02,95%CI=1.01-1.03,P=1.61×10-3),order.NB1n(OR=1.02,95%CI=1.01-1.03,P=2.00×10-3),and genus..Eubacteriumhalliigroup(OR=1.03,95%CI=1.01-1.04,P=6.97×10-4),among others.However,inverse Mendelian randomization analysis did not support a causal relationship.Sensitivity analyses showed there was no heterogeneity or horizontal pleiotropy.Conclusion This bidrectional Mendelian randomization study provides evidence of a clear causal relationship of gut microbiota on MetS and components,but does not support reverse causality.This finding provides new ideas for the management of MetS.Further randomized controlled trials are still needed in the future to elucidate the relationship between the effects of microbial agents such as probiotics on MetS.关键词
肠道微生物群/代谢综合征/孟德尔随机化/因果关系Key words
Gut microbiota/Metabolic syndrome/Mendelian randomization/Causal relationship分类
医药卫生引用本文复制引用
罗秀,麻钊丽,黄梦宇,任茜..肠道微生物群对代谢综合征的遗传预测因果效应研究[J].中国全科医学,2026,29(5):612-622,11.基金项目
甘肃省科技厅自然科学基金项目(21JR7RA381) （21JR7RA381）
甘肃省卫生健康行业科研项目(临床)(GSWSKY2020-07) （临床）
