中国全科医学2026，Vol.29Issue(6)：726-732,7.DOI:10.12114/j.issn.1007-9572.2024.0624
肌肉与脂肪比值对非超重/肥胖2型糖尿病的预测价值研究
Predictive Value of Muscle-to-Fat Ratio in Type 2 Diabetes Mellitus among Non-overweight/Obese People
摘要
Abstract
Background Type 2 diabetes mellitus(T2DM)onset is insidious in non-overweight/obese individuals,making early identification of risk factors for T2DM critically important.Muscle-to-fat ratio(MFR)is widely used in predicting metabolic diseases,but less analyzed in T2DM,especially in non-overweight/obese people with T2DM.Objective:To investigate the correlation of MFR with T2DM in non-overweight/obese individuals,and its predictive value.Methods This study enrolled non-overweight/obese adults who underwent health examinations in Xiyuan Hospital of China Academy of Chinese Medical Sciences from 2021 to 2024.Participants were stratified based on the T2DM status,and baseline levels were compared.Logistic regression and linear regression were used to analyze the correlation of MFR with T2DM risk and fasting plasma glucose(FPG)levels in non-overweight/obese individuals.To assess the robustness of findings,subgroup analyses were conducted based on gender,age,smoking status,alcohol consumption,and hypertension status.A receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of MFR in T2DM risk among non-overweight/obese individuals.Results A total of 1 021 non-overweight/obese participants were enrolled,including 113 T2DM patients.Logistic regression and linear regression results showed that in Model 1(unadjusted for covariates),each 1-unit increase in MFR among non-overweight/obese individuals was associated with a 36%reduction in T2DM risk(OR=0.36,95%CI=0.22 to 0.60,P<0.001),and a 0.26-unit decrease in FPG(β=-0.26,95%CI=-0.39 to-0.14,P<0.001).In Model 3 with adjustments for all covariates,each 1-unit increase in MFR was associated with a 29%reduction in T2DM risk(OR=0.29,95%CI=0.12 to 0.69,P=0.005)and a 0.28-unit decrease in FPG(β=-0.28,95%CI=-0.49 to-0.08,P=0.007).When MFR was treated as a categorical variable in Model 3,the risk of T2DM in the MFR Q4 group was 0.34 times that in the MFR Q1 group(OR=0.34,95%CI=0.12 to 0.93,P=0.036),and FPG levels decreased by 0.36 units(β=-0.36,95%CI=-0.63 to-0.09,P=0.009).Subgroup analysis revealed the correlation between MFR and FPG levels was more pronounced among smokers and individuals with hypertension.The area under the curve(AUC)of MFR in predicting T2DM risk among non-overweight/obese individuals was 0.635 4(95%CI=0.578 6 to 0.687 4),with an optimal cutoff of 1.080 1,a sensitivity of 46.90%and a specificity of 75.44%.Conclusion Among non-overweight/obese individuals,MFR exhibits a nonlinear negative correlation with T2DM risk and FPG levels.MFR demonstrates good predictive efficacy and can be used for early prediction of T2DM risk in non-overweight/obese populations.关键词
糖尿病,2 型/血糖/肌肉与脂肪比值/相关性研究/预测模型Key words
Diabetes mellitus,tpye 2/Blood glucose/Muscle-to-fat ratio/Correlation studies/Predictive modeling分类
医药卫生引用本文复制引用
李纪新,邱林杰,任燕,王文茹,李美洁,栗文婕,邹姹姹,吴梓敬,张晋..肌肉与脂肪比值对非超重/肥胖2型糖尿病的预测价值研究[J].中国全科医学,2026,29(6):726-732,7.基金项目
国家重点研发计划子课题(2018YFC2000600) （2018YFC2000600）
京薪火传承3+3项目(2023-SZ-A51) （2023-SZ-A51）
中国中医科学院科技创新工程(CI2021A03005) （CI2021A03005）
中国中医科学院西苑医院具有知识产权的医疗机构制剂和中药新药的研发与转化专项任务(XYZY0301-16) （XYZY0301-16）
