有色金属材料与工程2025，Vol.46Issue(6)：31-40,10.DOI:10.13258/j.cnki.nmme.20240406001
基于明胶/海藻酸钙的止血水凝胶的制备及性能研究
Preparation and performance of hemostatic hydrogel based on gelatin/calcium alginate
摘要
Abstract
Hemostatic hydrogel materials have broad clinical application prospects due to their excellent biocompatibility.However,existing hemostatic hydrogel materials often lack tissue adhesion and ideal mechanical properties.Inspired by marine mussels,dopamine(DA)from mussel adhesive proteins is grafted onto gelatin(Gel)molecules to synthesize dopamine-modified gelatin(Gel-DA)hydrogels with tissue adhesion.Subsequently,calcium alginate(CA)is combined with Gel-DA to construct Gel-DA/CA hydrogels with an interpenetrating polymer network(IPN)structure.Based on the content of calcium alginate in the hydrogels,they are named Gel-DA/CA-0.05,Gel-DA/CA-0.10,and Gel-DA/CA-0.15,respectively.The tissue adhesion,mechanical properties,and hemostatic performance of the hydrogels were tested to investigate the influence of calcium alginate content on their properties.Experimental results show that the tissue adhesion strengths of Gel-DA and Gel-DA/CA(0.05,0.10,0.15)hydrogels on pig skin are 18.32 kPa and 23.39 kPa,respectively,both higher than that of Gel(4.68±0.07)kPa.Gel-DA/CA-0.15 exhibits the strongest mechanical strength at a compression strain of 60%,with a stress of 259.17 kPa,which is much higher than the 94.65 kPa of Gel-DA hydrogels.In in vitro coagulation tests,Gel-DA/CA-0.15 shows optimal hemostatic performance:it can clot blood within 346 s and has a lower blood clotting index(BCI)at the same time.关键词
止血材料/水凝胶/明胶/海藻酸钙/多巴胺Key words
hemostatic materials/hydrogels/gelatin/calcium alginate/dopamine分类
医药卫生引用本文复制引用
张恒斌,耿芳,马凤仓..基于明胶/海藻酸钙的止血水凝胶的制备及性能研究[J].有色金属材料与工程,2025,46(6):31-40,10.基金项目
国家自然科学基金资助项目(51771119) （51771119）
上海市自然科学基金资助项目(17ZR1419600) （17ZR1419600）
