中国药理学与毒理学杂志2025，Vol.39Issue(11)：863-870,8.DOI:10.3867/j.issn.1000-3002.2025.08321
线粒体外膜转位酶20在肿瘤发展中调控作用研究进展
Research progress in the regulatory role of translocase of the outer mitochondrial membrane 20 in tumor development
摘要
Abstract
Mitochondrial dysfunction is a key driving force behind the occurrence and development of cancers,and the proper transport of proteins plays a central role in maintaining mitochondrial homeo-stasis.As a key translocation receptor in the mitochondrial outer membrane,translocase of outer mito-chondrial membrane 20(Tom20)is abnormally overexpressed in a wide range of cancer cells,and is closely related to their proliferation,invasion,drug resistance,and evasion of apoptosis.This review summarizes research progress in the roles of Tom20 in cancers,including hepatocellular carcinoma,lung cancer,colorectal cancer,and esophageal cancer,focusing on the effect of Tom20 on the survival and death of cancer cells by regulating apoptosis,pyroptosis,and autophagy.Studies have shown that Tom20 may not only promote tumor development but also act as a key factor inducing cell death under specific conditions,demonstrating a"double-edged sword"characteristic.In the future,targeted regula-tion based on Tom20 is expected to create new strategies for cancer treatment.But further in-depth research into its mechanisms of action and differences among tumor types is still needed to achieve precise and safe clinical application.关键词
线粒体外膜转位酶20/癌症/线粒体/细胞凋亡/细胞焦亡/细胞自噬Key words
Tom20/cancer/mitochondria/apoptosis/pyroptosis/autophagy分类
医药卫生引用本文复制引用
李汶遥,王茜茜,陈爽..线粒体外膜转位酶20在肿瘤发展中调控作用研究进展[J].中国药理学与毒理学杂志,2025,39(11):863-870,8.基金项目
国家自然科学基金(32501104) （32501104）
吉林省科技厅自然科学项目(YDZJ202401085ZYTS) （YDZJ202401085ZYTS）
吉林省大学生创新创业项目(S202413706001) （S202413706001）
美康大学生科研创新基金(2023JYMKZ001) National Natural Science Foundation of China(32501104) （2023JYMKZ001）
Natural Science Project of Department of Science and Technology of Jilin Province(YDZJ202401085ZYTS) （YDZJ202401085ZYTS）
Jilin University Student Innovation and Entrepreneur-ship Project(S202413706001) （S202413706001）
and Student Research and Innovation Fund of Meikang University(2023JYMKZ001) （2023JYMKZ001）
