中国药理学与毒理学杂志2025，Vol.39Issue(11)：871-878,8.DOI:10.3867/j.issn.1000-3002.2025.08480
胆固醇类似物在脂质纳米颗粒优化中的作用研究进展
Research progress of cholesterol analogs in lipid nanoparticles optimization
摘要
Abstract
Abstarct:Lipid nanoparticle(LNP)are currently the most widely used nucleic acid delivery vectors in clinical practice.As a key component of LNP,cholesterol contributes to the structural integrity of LNP by modulating the fluidity of bilayer membrane of lipids.However,conventional LNP are inadequate in delivery efficiency and tissue targeting,which hinders their applications in extrahepatic delivery.Therefore,the optimization of LNP,especially for cholesterol replacement,remains a priority in delivery system research.Cholesterol analogs have unique structures,and are promising substitutes due to their ability to preserve LNP stability enhance delivery efficiency and improve targeting specificity.Some analogs may even deliver therapeutic effects.This review summarizes recent advances in the design of LNP naturally occurring cholesterol analogs,such as phytosterols and saponins,as well as synthetic ones.This study is expected to provide insights into research in this field.关键词
脂质纳米颗粒/胆固醇/基因递送/植物甾醇/皂苷/胆固醇类似物Key words
lipid nanoparticle/cholesterol/gene delivery/phytosterols/saponins/cholesterol ana-logues分类
医药卫生引用本文复制引用
徐艺,王洪波,宋祥,王升启..胆固醇类似物在脂质纳米颗粒优化中的作用研究进展[J].中国药理学与毒理学杂志,2025,39(11):871-878,8.基金项目
国家重点研发计划(2018YFA0902300) National Key R&D Program of China(2018YFA0902300) （2018YFA0902300）
