中国内镜杂志2025，Vol.31Issue(12)：49-55,7.DOI:10.12235/E20240712
电子胃镜联合实验室指标检测在胃癌诊断中的价值及其与临床病理特征的关系
Clinical value of electronic esophagogastroduodenoscope combined with laboratory index detection in the diagnosis of gastric cancer and its relationship with clinicopathological features
摘要
Abstract
Objective To explore the value of electronic esophagogastroduodenoscope combined with laboratory indicators[serum carbohydrate antigen 724(CA724),carbohydrate antigen 19-9(CA19-9),microRNA-183(miRNA-183)and microRNA-144(miRNA-144)]in the diagnosis of gastric cancer and its relationship with clinicopathological features.Methods 122 patients with gastric cancer diagnosed by pathological examination from December 2022 to December 2023 were selected as the group A,and 130 patients with gastric benign tumor in the same period were selected as the group B.All the patients underwent electronic esophagogastroduodenoscope before being diagnosed by pathological examination.The positive rates of electronic esophagogastroduodenoscope,the levels of serum CA724,CA19-9,miRNA-183 and miRNA-144 in the two groups of patients were compared,and their diagnostic value for gastric cancer was analyzed.The positive rates of electronic esophagogastroduodenoscope and the levels of serum indicators in patients with gastric cancer with different pathological characteristics were compared.Results The positive rate of electronic esophagogastroduodenoscope,the levels of serum CA724,CA19-9 and miRNA-183 in group A were higher than those in group B,while the level of serum miRNA-144 was lower than that in group B.The differences were all statistically significant(P<0.05).Compared with individual diagnosis,the area under the curve(AUC)of the combined diagnosis of gastric cancer by the five was higher,and the difference was statistically significant(P<0.05).There were statistically significant differences in the positive rates of electronic esophagogastroduodenoscope and the levels of serum CA724,CA19-9,miRNA-183 and miRNA-144 among patients with different degrees of differentiation,lymph node metastasis and TNM stage(P<0.05).Conclusion Electronic esophagogastroduodenoscope has a good application effect in the diagnosis of gastric cancer and the evaluation of its pathological characteristics.Related laboratory indexes(serum CA724,CA19-9,miRNA-183 and miRNA-144)are closely related to the occurrence and pathological characteristics of gastric cancer.The combination of the five can improve the diagnostic efficiency of gastric cancer.关键词
胃癌/糖类抗原724(CA724)/糖类抗原19-9(CA19-9)/微RNA-183(miRNA-183)/微RNA-144(miRNA-144)/电子胃镜/诊断价值Key words
gastric cancer/carbohydrate antigen 724(CA724)/carbohydrate antigen 19-9(CA19-9)/microRNA-183(miRNA-183)/microRNA-144(miRNA-144)/electronic esophagogastroduodenoscope/diagnostic value分类
医药卫生引用本文复制引用
白锦秀,武文杰,杨小妹,孔淼源..电子胃镜联合实验室指标检测在胃癌诊断中的价值及其与临床病理特征的关系[J].中国内镜杂志,2025,31(12):49-55,7.基金项目
邯郸市科学技术局(No:23422083209) （No:23422083209）
