中国内镜杂志2025，Vol.31Issue(12)：64-69,6.DOI:10.12235/E20250278
乳果糖肠道准备优化方案的前瞻性随机对照试验
A prospective randomized controlled trial on the optimization protocol of lactulose intestinal preparation
摘要
Abstract
Objective To compare and analyze the application effects of lactulose and compound polyethylene glycol electrolyte powder(PEG)in intestinal preparation,in order to establish a new scheme for optimizing intestinal preparation.Methods A prospective randomized controlled trial was conducted.300 patients scheduled for colonoscopy from January 2023 to June 2024 were included and randomly divided into the lactulose group(n=150)and the PEG group(n=150).The intestinal cleanliness[Boston bowel preparation scale(BBPS)score and bowel bubble score(BBS)],the total number of bowel movements,the characteristics of the last stool,the detection rate of adenoma detection rate(ADR),the incidence of adverse reactions,and taste score of the two groups of patients were evaluated.Results The total BBPS score of the lactulose group was significantly higher than that of the PEG group,and the BBS score was significantly lower than that of the PEG group.The differences were statistically significant(P<0.05).The total number of bowel movements in the lactulose group was more than that in the PEG group,the proportion of watery stools in the final stool was significantly lower than that in the PEG group,the taste score was higher than that in the PEG group,and the incidence of adverse reactions was lower than that in the PEG group.The differences were all statistically significant(P<0.05).There was no statistically significant difference in ADR between the two groups of patients(P>0.05).Insufficient intestinal preparation was positively correlated with the body fat percentage of patients(r=0.265,P<0.05).Conclusion The effect of lactulose in intestinal preparation is close to that of compound PEG,but lactulose has a better intestinal field of vision,fewer bubbles,and a better taste than compound PEG.It is worthy of clinical promotion and application.关键词
肠道准备/乳果糖/复方聚乙二醇电解质散(PEG)/优化肠道准备/波士顿肠道准备量表(BBPS)/肠道气泡评分(BBS)Key words
bowel preparation/lactulose/compound polyethylene glycol electrolyte powder(PEG)/optimized bowel preparation/Boston bowel preparation scale(BBPS)/bowel bubble scale(BBS)分类
医药卫生引用本文复制引用
曹友红,袁晨,夏明霞,马亦旻,胡远胜,张康伟,唐月华,王芳,陈敏..乳果糖肠道准备优化方案的前瞻性随机对照试验[J].中国内镜杂志,2025,31(12):64-69,6.基金项目
江苏大学医学部"2023年江苏大学医教协同创新基金"(No:JDYY2023033) （No:JDYY2023033）
