中国药科大学学报2025，Vol.56Issue(6)：774-781,8.DOI:10.11665/j.issn.1000-5048.2025012301
外泌体在抗动脉粥样硬化中的应用研究进展
Research progress on the application of exosomes in atherosclerosis prevention
摘要
Abstract
Exosomes,as crucial mediators of intercellular communication,exhibit a wide range of biological functions in the onset and treatment of atherosclerosis(AS).Recent studies have indicated that exosomes can carry various active substances,including miRNA,lncRNA,proteins,and lipids.By regulating inflammatory responses,lipid metabolism,vascular endothelial function,and the immune microenvironment,they mediate the formation,progression,and reversal of AS at multiple levels.Specifically,miRNAs within exosomes can target and regulate the expression of inflammatory factors,inhibiting macrophage activation and foam cell formation.Meanwhile,exosomes derived from endothelial cells(EC)or stem cells can enhance vascular endothelial integrity and suppress endothelial dysfunction(ED).Furthermore,exosomes have been extensively explored as natural carriers for delivering drugs and nucleic acid molecules.Their membrane structure possesses excellent biocompatibility and targeting capabilities,showcasing significant potential as a novel therapeutic tool.Starting from basic mechanistic studies,this article summarizes the molecular pathways and key biological effects of exosomes in AS intervention,and further explores their current clinical application and multiple challenges they face,aiming to provide theoretical support and research directions for novel cardiovascular disease intervention strategies.关键词
外泌体/动脉粥样硬化/作用机制/组成Key words
exosomes/atherosclerosis/mechanisms of action/composition分类
医药卫生引用本文复制引用
邹子健,杨如月,奉建芳,涂亮星,程勐..外泌体在抗动脉粥样硬化中的应用研究进展[J].中国药科大学学报,2025,56(6):774-781,8.基金项目
江西省自然科学基金项目(20232BAB216128) （20232BAB216128）
江西省教育厅项目(GJJ2200977) （GJJ2200977）
江西中医药大学科技创新团队发展计划(CXTD-22004,CXTD-22008) （CXTD-22004,CXTD-22008）
江西中医药大学附属医院博士启动基金项目(23KYQDZJ02) This study was supported by the Natural Science Foundation of Jiangxi Province(20232BAB216128) （23KYQDZJ02）
Project of Jiangxi Provincial Department of Education(GJJ2200977) （GJJ2200977）
Science and Technology Innovation Team Development Plan of Jiangxi University of Chinese Medicine(CXTD-22004,CXTD-22008) （CXTD-22004,CXTD-22008）
Doctoral Startup Fund of the Affiliated Hospital of Jiangxi University of Chinese Medicine(23KYQDZJ02) （23KYQDZJ02）
