中国药科大学学报2025，Vol.56Issue(6)：782-792,11.DOI:10.11665/j.issn.1000-5048.2024122703
基于花生四烯酸代谢通路的多靶点抗炎药物研究进展
Research progress of the multi-target anti-inflammatory drugs based on the arachidonic acid pathway
摘要
Abstract
Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase,lipoxygenase,cytochrome P450 enzymes,and other metabolic pathways.Moreover,it plays a key role in the occurrence and development of inflammatory diseases.In recent years,multi-target drugs based on the arachidonic acid metabolic pathway have become an important direction of anti-inflammatory drug research.This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs,reviews the research progress of multi-target drug design,synthesis,and anti-inflammatory activity based on the arachidonic acid metabolic pathway,and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development,aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.关键词
炎症/花生四烯酸/抗炎药/多靶点药物Key words
inflammation/arachidonic acid/anti-inflammatory drugs/multitarget-drugs分类
医药卫生引用本文复制引用
乌丹,崔珑琛,徐富梅,王洁,续艳丽,张启立,李娇娇,赵磊..基于花生四烯酸代谢通路的多靶点抗炎药物研究进展[J].中国药科大学学报,2025,56(6):782-792,11.基金项目
国家自然科学基金项目(No.82160457,No.81660577) （No.82160457,No.81660577）
甘肃省科技计划资助项目(No.21JR7RA564) （No.21JR7RA564）
甘肃省青年科技基金计划项目(No.22JR11RA045) This work was supported by the National Natural Science Foundation of China(No.82160457,No.81660577) （No.22JR11RA045）
the Science and Technology Program of Gansu Province(No.21JR7RA564) （No.21JR7RA564）
and the Gansu Provincial Youth Science and Technology Foundation Program(No.22JR11RA045) （No.22JR11RA045）
