中国医学创新2025，Vol.22Issue(34)：25-29,5.DOI:10.3969/j.issn.1674-4985.2025.34.006
小骨窗血肿清除术治疗高血压脑出血的最佳治疗时机探究
Exploration of the Optimal Treatment Timing for Hypertensive Intracerebral Hemorrhage by Small Bone Window Hematoma Evacuation
摘要
Abstract
Objective:To explore the optimal treatment timing of small bone window hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage(HICH)and its impact on prognosis.Method:The clinical data of 100 patients with HICH treated by small bone window hematoma evacuation in Zhangjiakou Second Hospital from January 2022 to January 2024 were retrospectively analyzed.According to the operation time,the patients were divided into the observation group(within 6 hours after the onset)and the control group(6 to 24 hours after the onset),with 50 cases in each group.The perioperative indicators(intraoperative blood loss,hospitalization time),inflammatory factor indicators(IL-6,TNF-α,hs-CRP),angiotensin-1(Ang-1),endothelin-1(ET-1),antidiuretic hormone(ADH),Barthel index(BI),NIHSS score,the occurrence of complications and prognosis were compared between the two groups.Result:The intraoperative blood loss in the observation group was less than that in the control group,and the hospitalization time was shorter than that in the control group(P<0.05).The levels of IL-6,TNF-α and hs-CRP in the observation group at 7 d after the operation were lower than those in the control group(P<0.05).After 7 d of the operation,the levels of Ang-1,ET-1 and ADH in the observation group were lower than those in the control group(P<0.05).Three months after the operation,the BI score of the observation group was higher than that of the control group,and the NIHSS score was lower than that of the control group(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).The patients were followed up for 6 months after the operation,the survival rate of the observation group was higher than that of the control group(P<0.05).Conclusion:For patients with HICH,performing small bone window hematoma evacuation within 6 hours after the onset of the disease can reduce intraoperative blood loss,promote the recovery of self-care ability of life and neurological function of patients,inhibit the secretion of inflammatory factors,alleviate vascular function damage,improve their prognosis.关键词
小骨窗血肿清除术/高血压脑出血/最佳治疗时机Key words
Small bone window hematoma evacuation/Hypertensive intracerebral hemorrhage/Optimal treatment timing引用本文复制引用
温志强,潘瑞芬,刘豹,王丽丽..小骨窗血肿清除术治疗高血压脑出血的最佳治疗时机探究[J].中国医学创新,2025,22(34):25-29,5.基金项目
张家口市重点研发计划项目(2421113D) （2421113D）
