中国医学装备2025，Vol.22Issue(12)：50-54,5.DOI:10.3969/j.issn.1672-8270.2025.12.010
磁共振弥散张量成像对非动脉炎性前部缺血性视神经眼病变患者的视神经眶内段定量分析研究
Quantitative analysis of magnetic resonance DTI on the intra-orbital segment of the optic nerve of NAION patients
摘要
Abstract
Objective:To quantitatively analyze the intraorbital segment of the optic nerve in patients with non-arterial anterior ischemic optic neuropathy(NAION)by using magnetic resonance diffusion tensor imaging(DTI)technique,so as to explore the value of DTI technique in judging optic nerve damage due to NAION.Methods:A total of 39 NAION patients,who underwent plain scan examination of magnetic resonance on orbit at Eye Hospital China Academy of Chinese Medical Sciences during July 2024 and March 2025,were divided into case group,and other 39 healthy adults without ophthalmic diseases,who were similar at age and gender,were divided into health control group.All of them received contrast-enhanced uMR 660 1.5T magnetic resonance DTI to scan their orbit.After scanning,the images were transmitted into uWS-MR post processing workstation to measure partial anisotropy(FA)index,average apparent diffusion coefficient(ADC),relative anisotropy index(RA),average diffusion value(MD),volume ratio(VR),and T1 weight imaging(T1WI)axial diameter of the optic nerve of intraorbital segment of the optic nerve orbit.Each parameter(FA,ADC,RA and MD)of optic nerve DTI of two groups was compared between two groups.The sensitivity,specificity,area under curve(AUC)value of receiver operating characteristic(ROC)curve,and optimal threshold value(determined by Youden index)of each parameter was calculated by using a logistic regression model.Results:The diameter of optic nerve of case group was(4.11±0.52)mm,which was significantly lower than(4.34±0.52)mm of healthy control group,and the difference was significant(t=2.089,P＜0.05).The results of univariate analysis indicated that the FA and RA values of case group were significantly lower than those of healthy control group,while the ADC,MD and VR values of case group were significantly higher than those of healthy control group,and the differences were significant(t=4.360,6.829,4.558,3.705,4.809,P＜0.05).The results of binary logistic regression analysis showed that,the increases of ADC and MD values were independent risk factor of occurring ischemic optic neuropathy(OR=13.208,1.039,P＜0.05),while the increase of RA value was independent protective factor of occurring ischemic optic neuropathy(OR=0.000,P＜0.05),respectively.The diameter of the optic nerve did not show statistical significance in logistic regression.The AUC values of ADC,MD,and RA in diagnosing ischemic optic neuropathy were respectively 0.744(95%CI:0.644,0.844),0.692(95%CI:0.580,0.804)and 0.847(95%CI:0.767,0.927).The Yoden indices of them were respectively 0.400,0.467 and 0.578.The optimal cutoff values were respectively 1.239,67.750 and 0.375.In them,RA had the highest diagnostic value,while MD had lower diagnostic value.Conclusion:DTI parameters can reflect the microstructural damage of the optic nerve in NAION patients.In these parameters,diagnostic efficacy of RA is highest,which provides non-invasive,quantitative and microscopic assessment means for diagnosing NAION,and provide new imaging basis for clinical diagnosis and condition assessment.关键词
视神经眶内段/非动脉炎性前部缺血性视神经眼病变(NAION)/磁共振成像/弥散张量成像(DTI)Key words
Intraorbital segment of optic nerve/Non-arterial anterior ischemic optic neuropathy(NAION)/Magnetic resonance imaging/Diffusion tensor imaging(DTI)分类
医药卫生引用本文复制引用
高倩,李佳豪,赵子德,张春柱,吕喆..磁共振弥散张量成像对非动脉炎性前部缺血性视神经眼病变患者的视神经眶内段定量分析研究[J].中国医学装备,2025,22(12):50-54,5.基金项目
中国中医科学院眼科医院中央高水平医院项目资助(GSP5-87) Central High-Level Traditional Chinese Medicine Hospital Project of eye Hospital China Academy of Chinese medical science(GSP5-87) （GSP5-87）
