中国药房2025，Vol.36Issue(24)：3041-3047,7.DOI:10.6039/j.issn.1001-0408.2025.24.05
辽宁省49种降脂类药品的临床综合评价
Clinical comprehensive evaluation on 49 lipid-lowering drugs in Liaoning province
摘要
Abstract
OBJECTIVE To establish a comprehensive evaluation system for lipid-lowering drugs aligned with the clinical reality of Liaoning province,and to assess the commonly used lipid-lowering drugs in medical institutions within Liaoning province.METHODS A comprehensive evaluation system for lipid-lowering drugs of Liaoning province was established using literature analysis and the Delphi expert consultation method.A calculation method of"indicator weighted score"to"step-by-step aggregation"to"percentile standardization"was employed to enable horizontal comparison of 49 commonly used lipid-lowering drugs.RESULTS This study successfully established a comprehensive clinical evaluation system for lipid-lowering drugs of Liaoning province,comprising 7 first-level indicators,35 second-level indicators,and 116 scoring criteria.Among the first-level indicators,effectiveness(23%)had the highest weight,followed sequentially by safety(22%),innovativeness(15%),economy(13%),suitability(13%),accessibility(10%),and other attributes(4%).Among the 49 evaluated lipid-lowering drugs,the top 10 in overall score were all statins,with rosuvastatin calcium tablet B having the highest total score of 79.22.Inclisiran sodium injection had a total score of 57.14,performed outstandingly in safety(16.27)and innovativeness(11.27).CONCLUSIONS This study established a relatively comprehensive and detailed clinical evaluation system for lipid-lowering drugs of Liaoning province.Statins remain the cornerstone of lipid management.Most patients can primarily choose drugs like rosuvastatin tablet B,while PCSK9 inhibitors and fixed-dose combinations can be considered for patients with conventional treatment failure or statin intolerance.关键词
降脂类药品/临床综合评价/药品目录/安全性/有效性/辽宁省Key words
lipid-lowering drugs/clinical comprehensive evaluation/drug list/safety/effectiveness/Liaoning province分类
医药卫生引用本文复制引用
郭静文,陈军霖,梁秀娜,蔡爽..辽宁省49种降脂类药品的临床综合评价[J].中国药房,2025,36(24):3041-3047,7.基金项目
中国青年创业就业基金会项目(No.2023A01-12) （No.2023A01-12）
