中国药房2025，Vol.36Issue(24)：3073-3078,6.DOI:10.6039/j.issn.1001-0408.2025.24.10
卡匹色替联合氟维司群二线治疗HR+/HER2-晚期乳腺癌的成本-效用分析
Cost-utility analysis of capivasertib combined with fulvestrant in the second-line treatment of HR+/HER2-advanced breast cancer
摘要
Abstract
OBJECTIVE To evaluate the cost-utiliby of capivasertib combined with fulvestrant for the second-line treatment of hormone receptor-positive/human epidermal growth factor receptor-2-negative(HR+/HER2-)advanced breast cancer from the perspective of the Chinese healthcare system.METHODS A partitioned survival model was constructed using clinical data from the CAPItello-291 trial.Costs and quality-adjusted life years(QALYs)were used as the output indicators of the model,and the incremental cost-effectiveness ratio(ICER)was used as the evaluation indicator of the model.Using three times the per capita gross domestic product(GDP)of China in 2024 as the willingness-to-pay threshold(WTP),this study analyzed the cost-utility of capivasertib combined with fulvestrant versus fulvestrant monotherapy in the treatment of HR+/HER2-advanced breast cancer,and conducted sensitivity analysis and scenario analysis under conditions where the price of capivasertib was reduced by 50%,60%,70%and 95%,respectively.RESULTS The results of the basic analysis showed that compared with the fulvestrant monotherapy regimen,the ICER of capivasertib combined with fulvestrant was 843 038.46 yuan/QALY,which was higher than the WTP(287 247 yuan/QALY).The one-way sensitivity analysis revealed that the top three factors with the most substantial influence on ICER were the utility value in the progression disease state,the price of capivasertib,and the utility value in the progression free survival state.Probabilistic sensitivity analysis demonstrated the robustness of the basic analysis results.Scenario analysis revealed that even if the price of capivasertib were reduced by 95%,capivasertib combined with fulvestrant did not exhibit cost-effectiveness at the current WTP.CONCLUSION At a WTP of three times China's GDP per capita in 2024,compared to fulvestrant monotherapy,capivasertib combined with fulvestrant as the second-line treatment for HR+/HER2-advanced breast cancer is not cost-effective.关键词
卡匹色替/氟维司群/晚期乳腺癌/激素受体/人表皮生长因子受体2/分区生存模型/成本-效用分析Key words
capivasertib/fulvestrant/advanced breast cancer/hormone receptor/human epidermal growth factor receptor-2/partitioned survival model/cost-utility analysis分类
医药卫生引用本文复制引用
张扬,康朔,王晓晖,侯奕冰,付祥霞,刘焕龙..卡匹色替联合氟维司群二线治疗HR+/HER2-晚期乳腺癌的成本-效用分析[J].中国药房,2025,36(24):3073-3078,6.基金项目
河北省高等教育教学改革研究与实践项目(No.2021GJJG145) （No.2021GJJG145）
