摘要
Abstract
Objective:To explore the relationship between serum 25-hydroxyvitamin D in premature infants and bronchopulmonary dysplasia.Method:The study selected 74 premature infants with a gestational age of less than 34 weeks admitted to the Putian Branch of Fujian Provincial Neonatal Rescue Center from March 2022 to March 2025 as the research subjects.They were divided into the non-BPD group and the BPD group according to whether bronchopulmonary dysplasia(BPD)occurred 28 days after birth.The general information of the two groups of children and the levels of 25-(OH)D at birth and 28 days of 25-(OH)D were compared.Meanwhile,the factors with differences in the analysis of influencing factors of the two groups of children were included in the logistic regression model for analysis.Result:There were no statistically significant differences in gestational age,birth weight,gender,mode of delivery,gestational diabetes,gestational hypertension,neonatal asphyxia and PDA between the two groups of children(P>0.05).There were statistically significant differences between the BPD group and the non-BPD group in terms of Apgar score,mechanical ventilation time,length of hospital stay,non-invasive respiratory support,neonatal pneumonia,neonatal sepsis,25-(OH)D at birth,and 25-(OH)D at 28 days(P<0.05).Among the children in the BPD group,there were 29 children with mild/moderate BPD and 8 children with severe BPD.The levels of 25-(OH)D at birth and 28 days of 25-(OH)D in the severe BPD group were lower than those in the mild/moderate BPD group(P<0.05).Multivariate logistic regression showed that mechanical ventilation time,length of hospital stay,non-invasive respiratory support,neonatal pneumonia,neonatal sepsis,and 28-day 25-(OH)D were significantly correlated with the occurrence of BPD in children(P<0.05).Conclusion:Serum 25-hydroxyvitamin D at birth and 28 days in premature infants is correlated with the occurrence and severity of BPD.Monitoring and early supplementation of vitamin D can improve prognosis.关键词
早产儿25-羟维生素D/支气管肺发育不良/影响因素Key words
25 hydroxyvitamin D in premature infants/Bronchopulmonary dysplasia/Influence factor
