中药材2025，Vol.48Issue(5)：1174-1179,6.DOI:10.13863/j.issn1001-4454.2025.05.018
野八角果实的化学成分研究
Chemical Constituents from the Fruits of Illicium simonsii
摘要
Abstract
Objective:To study the chemical constituents from the fruits of Illicium simonsii.Methods:The compounds from the eth-yl acetate fraction of the ethanol extract of Illicium simonsii fruits were isolated and purified by silica gel column chromatography,Sepha-dex LH-20 gel column chromatography,RP-C18 column chromatography and semi-preparative high performance liquid chromatography,and the structures of the compounds were identified by spectral data and literature.The in vitro anti-human colon cancer cell(HCT-116)activity of the compounds was tested by MTT assay.Results:Eighteen compounds were isolated from the fruits of Illicium simonsii and i-dentified as henrylactone A(1),oligandrumin D(2),veranisatin D(3),blumenol A(4),blumenol B(5),prinsepiol(6),7S,8R-di-hydrodehydrodiconiferyl alcohol(7),sinensiol G(8),dehydrodiconiferyl alcohol(9),rhoifoline B(10),4-methoxy-N-methyl-2-quinolo-ne(11),trans-N-p-coumaroyltyramine(12),p-hydroxybenzaldehyde(13),vanillyl alcohol(14),quercetin(15),mexoticin(16),samwi-rin(17),(-)-massoniresinol(18),respectively.In vitro experiments showed that compounds 1 and 11 had inhibitory effect on HCT-116 cells.Conclusion:Among them,compounds 4 to 6,8,10 to 12,14,16,17 are isolated from Illicium genus for the first time,compound 18 is isolated from Illicium simonsii for the first time.Compounds 1 and 11 show potential antitumor activity with IC50 of(3.18±0.11)μmol/L and(2.43±0.12)μmol/L,respectively.关键词
野八角/化学成分/henrylactone A/抗癌活性Key words
Illicium simonsii Maxim./Chemical constituents/Henrylactone A/Anticancer activity分类
医药卫生引用本文复制引用
梅咏妍,许旭东,马国需,吴燕春,莫静雅,刘泉,袁经权..野八角果实的化学成分研究[J].中药材,2025,48(5):1174-1179,6.基金项目
国家自然科学基金项目(82060700) （82060700）
广西创新驱动发展专项基金项目(2022JBGS042) （2022JBGS042）
