中医临床研究2025，Vol.17Issue(26)：27-33,7.DOI:10.3969/j.issn.1674-7860.2025.26.003
基于"脾-线粒体-肠道菌群"探讨从脾论治卵巢衰老
Treating ovarian aging from the perspective of spleen based on the correlation of"spleen-mitochondria-gut microbiota"
摘要
Abstract
Ovarian aging refers to a group of gynecological disorders characterized by progressive decline or premature failure of ovarian function,significantly impacting women's reproductive health and quality of life.Modern medical research has revealed that mitochondrial dysfunction and gut microbiota dysbiosis are closely associated with diminished ovarian function.Mitochondria are the energy factories of cells,and mitochondrial dysfunction directly impairs the energy supply for ovarian cells,affecting normal physiological function of ovary.Gut microbiota dysbiosis,meanwhile,indirectly interferes with ovarian function through immune,endocrine,and chronic inflammatory pathways.In traditional Chinese medicine(TCM)gynecology,ovarian aging is typically treated from the perspective of kidney deficiency[including both Yin(阴)and Yang(阳)deficiency,or liver-kidney Yin deficiency]based on syndrome differentiation.However,clinical practice reveals that many patients also exhibit insufficiency of spleen-stomach function.According to TCM theory,the spleen and stomach are the foundation of the body after birth,and are responsible for transforming food into Qi(气)and blood,which nourish the congenital reproductive essence and uterus.Modern research has confirmed that there is a certain connection between the concept of spleen in TCM and mitochondria as well as gut microbiota.Impaired transportation and transformation due to spleen deficiency corresponds to nutrient absorption disorders and metabolic waste accumulation caused by inefficient mitochondrial productivity and gut microbiota dysbiosis,and the chronic inflammation caused by both of them precisely aligns with the TCM concept of"dampness-turbidity internal obstruction"trapping spleen Yang.The therapy of fortifying the spleen and benefiting Qi may positively impact ovarian function by optimizing mitochondrial function and regulating gut microbiota homeostasis.This process is in line with the TCM principle of spleen generating Qi and blood to nourish the congenital essence and the uterus.In view of this,in this study,starting from the correlation of"spleen-mitochondria-intestinal microbiota",treating ovarian aging from the perspective of spleen is explored.This approach can not only enrich the relevant theory in TCM,but also may offer more effective TCM strategies for clinical treatment of ovarian aging,providing expanded therapeutic options for patients.关键词
卵巢衰老/从脾论治/线粒体/肠道菌群Key words
Ovarian aging/Treatment from the perspective of spleen/Mitochondria/Gut microbiota分类
医药卫生引用本文复制引用
翟亚悦,袁山政,张燕雨,高宁,李泽琳,廖莎,郑伟,徐慧军..基于"脾-线粒体-肠道菌群"探讨从脾论治卵巢衰老[J].中医临床研究,2025,17(26):27-33,7.基金项目
山东省中医药科技项目(M-2022017). （M-2022017）
