中医临床研究2025，Vol.17Issue(26)：38-44,7.DOI:10.3969/j.issn.1674-7860.2025.26.005
基于"脾-线粒体"相关探讨癌因性疲乏的发病机制
Exploring the pathogenesis of cancer-related fatigue based on the"spleen-mitochondrion"correlation
摘要
Abstract
Cancer-related fatigue(CRF)is a multidimensional subjective fatigue of physical,emotional,and cognitive exhaustion experienced by cancer patients induced by the occurrence,progression and therapeutic interventions of tumors.It is characterized by persistence and non-specificity,and is difficult to be relieved after conventional rest.The pathogenesis of CRF is incompletely elucidated currently,involving multi-factor such as inflammatory responses,adenosine triphosphate(ATP)metabolic abnormalities,neuroendocrine dysregulation,and the occurrence,progression and treatment of tumor.Mitochondria are the central organelles of cellular energy metabolism,and their dysfunction plays a pivotal role in the occurrence and progression of CRF.Mitochondria generate ATP via oxidative phosphorylation,providing energy support for physiological activities of visceral organs.Research has found significant parallels between the physiological functions and pathological manifestations of the spleen in traditional Chinese medicine(TCM)and mitochondrial dynamics,and mitochondrial dysfunction might be a critical factor in the occurrence and progression of spleen deficiency type CRF.In state of spleen deficiency,impaired digestive and transportative functions of the body lead to deficient Qi(气)and blood production and disrupted fluid metabolism.These pathological changes correlate positively with mitochondrial depletion,ultrastructural abnormalities,and functional impairment,resulting in energy metabolic disorders and fatigue symptoms.Such mitochondrial function alteration is not only an important pathological basis of spleen deficiency syndrome,but may also exacerbate the clinical symptoms of CRF by affecting energy supply.In TCM theory,the spleen is recognized as the foundation of postnatal vitality,responsible for metabolizing nutrients and distributing essential substances to nourish all organs and tissues,which is a process obviously analogous to mitochondrial energy metabolism.In this study,the relationship between mitochondria and the occurrence and development of CRF is explored from the perspective of mitochondria,focusing on the correlation of mitochondrial dysfunction and spleen deficiency syndrome,such as correcting spleen deficiency state by regulating mitochondrial function and ameliorating energy metabolism,so as to provide more effective therapeutic strategies for CRF patients,ultimately improving their quality of life.关键词
癌因性疲乏/线粒体/脾虚/能量代谢Key words
Cancer-related fatigue/Mitochondrion/Spleen deficiency/Energy metabolism分类
医药卫生引用本文复制引用
杨钦焜,赵瑞国,宋文杰,王宁..基于"脾-线粒体"相关探讨癌因性疲乏的发病机制[J].中医临床研究,2025,17(26):38-44,7.基金项目
辽宁省教育厅面上项目:基于肌肉干细胞研究益气健脾抗癌方治疗结肠癌CRF的作用机制(JYTMS20231829) （JYTMS20231829）
辽宁省科技计划联合计划(基金)面上项目:基于"脾为谏议之官"探讨益气健脾抗癌方调控miR-190a-3p/VEGF-A/免疫稳态促进大肠癌细胞凋亡的机制研究(2023-MSLH-157). （基金）
