中国真菌学杂志2025，Vol.20Issue(6)：594-598,5.DOI:10.3969/j.issn.1673-3827.2025.06.006
某医院耳念珠菌的耐药性特征及溯源分析
Analysis of the drug resistance characteristics and molecular traceability of Candida auris in a certain hospital
摘要
Abstract
Objective To investigate the species identification,drug sensitivity and genomic characteristics of Candida auris in Hebei Yanda Hospital from January 1,2025 to June 30,2025,and to provide a basis for formulating infection control strategies within the hospital.Methods Two cases of C.auris were traced back to their sources.The initial identification was confirmed by MALDI-TOF MS mass spectrometry.The minimum inhibitory concentrations of antifungal drugs were detected using Sensititre YeastOne,and genomic sequencing analysis was conducted.Results The initial identification was C.haemulonii and C.famata,which were confirmed as C.auris by Vitek MS mass spectrometry.The drug sensitivity test showed that both strains were significantly resistant to fluconazole,and they were highly similar to the South Asian clade B8441(Clade I)type and had variations in the drug resistance genes ERG11_Y132F,TAC1B_A583S and FCY1_S70R.Conclusions This study reveals the drug resistance characteristics and molecular traceability of C.auris in Hebei Yanda Hospital,which is a South Asian clade B8441(Clade I)type resistant to fluconazole.It provides a scientific basis for establishing an early warning mechanism and optimizing the diagnosis and treatment plan in clinical practice.关键词
耳念珠菌/流行特征/质谱检测/耐药性Key words
Candida auris/epidemiological characteristics/mass spectrometry validation/drug resistance引用本文复制引用
栗方,张艳利,王娟,王诗淇,张浩,王金菊,王军爽..某医院耳念珠菌的耐药性特征及溯源分析[J].中国真菌学杂志,2025,20(6):594-598,5.基金项目
河北省医学科学研究课题计划项目(20261154) （20261154）
