中医临床研究2025，Vol.17Issue(27)：20-24,5.DOI:10.3969/j.issn.1674-7860.2025.27.004
从肿瘤血管化浅析疏肝解毒法辨治乳腺癌
A brief analysis of treating breast cancer by the method of soothing the liver and detoxifying from the perspective of tumor vascularization
摘要
Abstract
Breast cancer is a malignant tumor that seriously threatens women's health,and its high invasiveness is closely related to tumor vascularization.Seeking effective treatment strategies for the disease has become a key point in clinical practice.In this paper,based on the in-depth discussion of relevant traditional Chinese medicine theory,it is proposed that the core pathogenesis of breast cancer is deficient vital energy and toxin accumulation,the disorder of internal organs and the weakness of vital energy are the fundamental factors of the disease's occurrence and development,while"the mutual accumulation of pathogenic toxins such as depression,phlegm,and blood"is the key factor of the progression of the disease.Further combined with the research on tumor vascularization in modern medicine,the similarity between the pathological characteristics of tumor angiogenesis and the"tortuous meridians"in traditional Chinese medicine was analyzed,and the intrinsic connection between the pathogenesis of"blood stasis and toxin damaging meridians"and the growth of tumor vascular endothelium,blood supply,and metastasis tendency was interpreted.On this basis,two major targets for regulating tumor vascularization by the method of soothing the liver and detoxifying were proposed as followed:By soothing the liver and regulating the smooth flow of Qi(气),the initiating factors of angiogenesis were blocked,and the abnormal secretion of pro-angiogenic factors was inhibited from the source;By detoxifying,removing blood stasis and unblocking meridians,it directly inhibited angiogenesis and ameliorated the tumor microenvironment.Studies have shown that the method of soothing the liver and detoxifying provides new theoretical basis and potential therapeutic directions for the diagnosis and treatment of breast cancer from the dual dimensions of traditional Chinese medicine pathogenesis and modern medical mechanisms,which is of great significance for expanding the application of traditional Chinese medicine in the treatment of breast cancer.关键词
乳腺癌/肿瘤血管化/疏肝解毒法/瘀毒损络Key words
Breast cancer/Tumor vascularization/Method of soothing the liver and detoxifying/Blood stasis and toxin damaging meridians分类
医药卫生引用本文复制引用
彭莉,李琳霈..从肿瘤血管化浅析疏肝解毒法辨治乳腺癌[J].中医临床研究,2025,17(27):20-24,5.基金项目
国家自然科学基金青年科学基金项目(82205224) （82205224）
湖南省中医药研究院重点课题项目(202116). （202116）
