肿瘤防治研究2025，Vol.52Issue(12)：959-965,7.DOI:10.3971/j.issn.1000-8578.2025.25.0766
儿童血液肿瘤造血干细胞移植后合并侵袭性真菌感染的诊治与挑战
Diagnostic Treatment and Challenges of Combined Invasive Fungal Infections After Hematopoietic Stem Cell Transplantation for Hematological Neoplasms in Children
摘要
Abstract
Invasive fungal disease(IFD)has a high incidence in patients with hematologic malignancies who have undergone hematopoietic stem cell transplantation,particularly in children.IFD increases mortality and presents multiple challenges in diagnosis and treatment.Among these fungi,Aspergillus,Candida,and Trichoderma are the main pathogens.Infections caused by these fungi usually present with nonspecific symptoms such as fever and dyspnea,further complicating the diagnosis.Invasive Candida infections can manifest as candidemia or chronic disseminated candidiasis(eg.involving the liver and spleen).The latter condition can be accompanied by localized symptoms such as right upper quadrant tenderness and abdominal pain,which further complicates the early diagnosis of IFD.The early diagnosis and effective treatment of IFD after hematopoietic stem cell transplantation for pediatric hematologic neoplasms require multiple tools to overcome clinical challenges and improve patient prognosis.关键词
侵袭性真菌病/侵袭性真菌感染/血液肿瘤/儿童/诊断治疗Key words
Invasive fungal disease/Invasive fungal infections/Hematological neoplasms/Children/Diagnostic treatment分类
医药卫生引用本文复制引用
郭智..儿童血液肿瘤造血干细胞移植后合并侵袭性真菌感染的诊治与挑战[J].肿瘤防治研究,2025,52(12):959-965,7.基金项目
Shenzhen Medical Research Fund(No.B2402027) （No.B2402027）
NHC Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital)(No.2023HYX033) （Mianyang Central Hospital）
Shenzhen Nanshan District Health System Science and Technology Major Project(No.NSZD2023018) （No.NSZD2023018）
Nanshan District Medical Key Discipline Development Funding Program,Shenzhen 深圳市医学研究专项(B2402027) （B2402027）
国家卫生健康委员会核技术医学转化重点实验室开放课题(2023HYX033) （2023HYX033）
深圳市南山区卫生健康系统科技重大项目(NSZD2023018) （NSZD2023018）
深圳市南山区区级医学重点学科建设资助项目 （）
