肿瘤防治研究2025，Vol.52Issue(12)：1021-1028,8.DOI:10.3971/j.issn.1000-8578.2025.25.0405
中药单体及复方通过调控糖代谢重编程抗肺癌的作用机制研究进展
Research Progress on Mechanism of Chinese Herbal Monomers and Compound Formulas Against Lung Cancer Through Glucose Metabolic Reprogramming
摘要
Abstract
Glucose metabolic reprogramming is important in promoting the occurrence and development of malignant tumors and meeting the high demands of the malignant proliferation of tumor cells.An in-depth investigation of the mechanism of glucose metabolic reprogramming in lung cancer is important for the development of effective therapeutic strategies for lung cancer.Traditional Chinese medicine(TCM)is characterized by multiple components,targets,and pathways and can exert antitumor effects through multiple mechanisms.This article illustrates systematically the mechanism of action of Chinese herbal monomers and compound formulas regulating glucose metabolic reprogramming in lung cancer and explores deeply their regulatory effects on key enzymes of glycolysis and metabolism-related signaling pathways,and their potential in overcoming the drug resistance of lung cancer.It aims to provide a reference basis for the study of therapeutic targets and mechanisms of action of TCM in prevention and treatment of lung cancer and theoretical sources for the research and development of new medicines.关键词
中药/单体或复方/糖代谢重编程/肺癌/作用机制Key words
Traditional Chinese medicine/Monomer or compound/Glucose metabolic reprogramming/Lung cancer/Mechanism分类
医药卫生引用本文复制引用
王真,郭红磊,王爱迪,马霖,刘宝山..中药单体及复方通过调控糖代谢重编程抗肺癌的作用机制研究进展[J].肿瘤防治研究,2025,52(12):1021-1028,8.基金项目
National Natural Science Foundation of China(No.82374354) （No.82374354）
National Natural Science Foundation of China Youth Fund(No.82305127) 国家自然科学基金面上项目(82374354) （No.82305127）
国家自然科学基金青年基金(82305127) （82305127）
