重庆医学2025，Vol.54Issue(12)：2727-2732,6.DOI:10.3969/j.issn.1671-8348.2025.12.002
经颅黑质超声联合S1P、HDL-C在帕金森病早期诊断中的价值研究
Study on the value of transcranial substantia nigra ultrasound combined with S1P and HDL-C in the early diagnosis of Parkinson's disease
摘要
Abstract
Objective To explore the value of substantia nigra hyperechogenicity transcranial sonogra-phy(SN-TCS)combined with sphingosine 1-phosphate(S1P)and HDL-C in the early diagnosis of Parkin-son's disease(PD).Methods A total of 98 PD patients admitted to this hospital from October 2021 to Octo-ber 2023 were selected as the PD group,and another 100 healthy individuals who were admitted for health check-ups during the same period were selected as the control group.The conditions of the PD group were e-valuated according to the Hoehn-Yahr(H-Y)staging criteria.Patients with a score≤2.0 were classified as mild patients(n=34),and those with a score≥2.5 were classified as moderate to severe patients(n=64).Both two groups underwent SN-TCS examination.The level of S1P was detected by ELISA,and the level of HDL-C was detected by an automatic biochemical analyzer.The differences in substantia nigra(SN)hypere-choic area,S1P and HDL-C among each group were compared.Multivariate logistic regression was used to an-alyze the influencing factors of moderate to severe PD occurrence.The receiver operating characteristic(ROC)curve was drawn to analyze the application value of the three indicators in the prediction of PD disease.Results Compared with the control group,the mini-mental state examination(MMSE)score,Montreal cognitive assessment(MoCA)score,S1P and HDL-C levels in the PD group were lower,while the SN hyperechoic area was larger(P<0.05).Compared with mild patients,moderate to severe patients had lower MMSE score,MoCA score,S1P and HDL-C levels,higher unified Parkinson's disease rating scale(UPDRS)Ⅲ score,and larger SN hy-perechoic area(P<0.05).The results of multivariate logistic regression analysis showed that high UPDRSⅢscore and increased SN hyperechoic area were risk factors for the occurrence of moderate to severe PD,while high MMSE and MoCA scores and high levels of S1P and HDL-C were protective factors for the occurrence of moderate to severe PD(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)for the combined prediction of moderate to severe PD by SN hyperechoic area,S1P,and HDL-C was 0.821(0.769-0.873),which was higher than that of a single indicator(P<0.05).Conclusion SN-TCS com-bined with S1P and HDL-C examinations is helpful to improve the accuracy of PD diagnosis results.关键词
帕金森病/经颅黑质超声/黑质强回声面积/鞘氨醇1磷酸/高密度脂蛋白-胆固醇Key words
Parkinson's disease/substantia nigra hyperechogenicity transcranial sonography/substan-tia nigra hyperechoic area/sphingosine 1 phosphate/high density lipoprotein-cholesterol分类
医药卫生引用本文复制引用
LIU Lan,DUAN Xunxin,CHAI Jingyan,GUO Qin..经颅黑质超声联合S1P、HDL-C在帕金森病早期诊断中的价值研究[J].重庆医学,2025,54(12):2727-2732,6.基金项目
江西省卫生健康委员会科技计划项目(202410686). （202410686）
