重庆医学2025，Vol.54Issue(12)：2755-2758,2765,5.DOI:10.3969/j.issn.1671-8348.2025.12.007
脑白质高信号严重程度的影响因素分析
Analysis of risk factors for the severity of white matter hypersignaling
摘要
Abstract
Objective To explore the risk factors for the severity of white matter hypersignaling in the T2-weighted fluid-attenuated inversion recovery sequence(T2WI-FLAIR)of MRI in hospitalized patients.Methods A retrospective analysis was conducted on the clinical data of 292 inpatients who underwent MRI in this hospital from January 2021 to December 2022.Demographic characteristics(age,gender),past medical history(hypertension,diabetes,hyperlipidemia,smoking and drinking history),and laboratory indicators(blood uric acid,cystatin C levels)were collected.WMH classification was performed based on the T2WI-FLAIR sequence according to the Fazekas scoring criteria:a total score of 1-2 points was included in the mild group(n=153),and a score of 3-6 points was included in the moderate to severe group(n=139).Univariate analysis was used to screen for potential risk factors related to severity,and binary logistic regression was fur-ther used to determine the independent risk factors for moderate to severe WMH.Results Compared with the mild group,the age of the moderate to severe group[74(67,81)years old vs.67(57,74)years old],the inci-dence of hypertension(71.22%vs.51.63%),and the proportion of hypercystatin C-emia(28.06%vs.15.69%)were significantly increased(P<0.05).Logistic regression analysis showed that advanced age(OR=1.065,95%CI:1.039-1.094)and hypertension(OR=2.331,95%CI:1.377-3.997)were independ-ent risk factors for moderate to severe WMH(P<0.05).Conclusion The age of hospitalized patients and the history of hypertension are independently associated with moderate to severe WMH.关键词
磁共振成像/液体衰减反转恢复序列/脑白质高信号/Fazekas评分/风险因素Key words
magnetic resonance imaging/liquid attenuation inversion recovery sequence/white matter hyperintensity/fazekas score/risk factor分类
医药卫生引用本文复制引用
WANG Haotian,LIANG Ruipeng,LI Yonglong,ZHOU Jun,JIANG Linrong..脑白质高信号严重程度的影响因素分析[J].重庆医学,2025,54(12):2755-2758,2765,5.基金项目
重庆市教育委员会科学技术研究项目(KJQN202400112) （KJQN202400112）
重庆市科卫联合医学科研项目(2024QNXM042). （2024QNXM042）
