广东医学2025，Vol.46Issue(12)：1800-1808,9.DOI:10.13820/j.cnki.gdyx.20252629
肥胖和血脂相关指数预测代谢相关脂肪性肝病的有效性
Predictive value of obesity-and lipid-related indices for metabolic associated fatty liver disease
摘要
Abstract
Objective Traditional and non-traditional lipid indices have been shown to closely associate with metabolic associated fatty liver disease(MAFLD).This study aimed to analyze the associations between multiple non-traditional lipid indices and MAFLD,and to compare their diagnostic value.Methods A retrospective study was con-ducted on individuals undergoing health examinations from January 2021 to December 2023.Logistic regression models were used to evaluate the associations of body mass index(BMI),fasting glucose to high-density lipoprotein cholesterol ratio(GHR),GHR-BMI,triglyceride-glucose(TyG)index,TyG-BMI,triglycerides(TG),TG/HDL-C,and TG/HDL-C-BMI with MAFLD.Receiver operating characteristic(ROC)curves were employed to assess the diagnostic accuracy of these obesity-and lipid-related indices and their combinations.Results After adjusting for potential con-founders,multivariate logistic regression showed that all indices were independently associated with MAFLD,with TyG demonstrating the strongest correlation.ROC analysis indicated that GHR-BMI had better predictive performance than TyG and TG alone.The combined model of GHR-BMI and TyG-BMI demonstrated the highest predictive performance(overall population:AUC=0.85,95％CI=0.84-0.86;men:AUC=0.83,95％CI=0.82-0.84;women:AUC=0.88,95％CI=0.87-0.89).Notably,all indices exhibited higher predictive ability in women and younger individuals,with GHR-BMI and GHR-BMI combined with TG/HDL-C-BMI reaching an AUC of 0.91 in young women.Conclusion TyG-BMI,GHR-BMI,and their combined models(e.g.,GHR-BMI+TyG-BMI,GHR-BMI+TG/HDL-C-BMI,TyG-BMI+TG/HDL-C-BMI)are effective predictors of MAFLD,with the combination of GHR-BMI and TyG-BMI showing the greatest predictive potential.关键词
代谢相关脂肪性肝病/肥胖和血脂相关指数/GHR相关指标/TyG相关指标/受试者工作特征Key words
metabolic associated fatty liver disease/obesity-and lipid-related indices/GHR-related indi-ces/TyG-related indices/receiver operating characteristic分类
医药卫生引用本文复制引用
YOU Meng-ting,ZHANG Ze-dan,SU Ji-yuan,BAO Wei-wei..肥胖和血脂相关指数预测代谢相关脂肪性肝病的有效性[J].广东医学,2025,46(12):1800-1808,9.基金项目
福建省自然科学基金资助项目(2024J011150) （2024J011150）
