广东医学2025，Vol.46Issue(12)：1821-1825,5.DOI:10.13820/j.cnki.gdyx.20252910
镍纹样蛋白介导运动防治代谢性疾病的研究进展
Progress in the role of meteorin-like protein in exercise-mediated prevention and treatment of metabolic disea-ses
摘要
Abstract
Metabolic diseases have become a major global public health challenge,and exercise,as a safe and ef-fective non-pharmacological intervention,has been widely applied in the prevention and treatment of obesity,type 2 dia-betes mellitus(T2DM),and nonalcoholic fatty liver disease(NAFLD),yet the underlying regulatory mechanisms remain incompletely understood.Meteorin-like protein(Metrnl),also known as Subfatin,Cometin,IL-39,or IL-41,is a newly identified secreted protein associated with metabolic regulation that enhances insulin sensitivity,alleviates inflamma-tory responses,and modulates energy homeostasis,thereby playing an important role in preventing and treating obesity,T2DM,and related metabolic disorders.Notably,exercise increases Metrnl expression in metabolic tissues such as skele-tal muscle and adipose tissue.This review summarizes recent domestic and international research on the role of Metrnl in exercise-mediated prevention and treatment of metabolic diseases and analyzes its potential mechanisms of action,provi-ding a theoretical basis for novel molecular targets and interventions in the management of metabolic disorders.关键词
运动/镍纹样蛋白/代谢性疾病Key words
exercise/meteorin-like protein/metabolic diseases分类
医药卫生引用本文复制引用
CHEN Si-qi,HAN Xiao,PANG Wen-tao,MA Pei-hong,WU Si-nuo,TANG Dong-ning,WU Si-quan,XIA Qing..镍纹样蛋白介导运动防治代谢性疾病的研究进展[J].广东医学,2025,46(12):1821-1825,5.基金项目
天津市教委科研计划项目(2023KJ141) （2023KJ141）
天津市教育委员会科研计划项目(2024KJ002) （2024KJ002）
天津中医药大学第十五届大学生科技创新基金项目(ZR1522) （ZR1522）
