广西医学2025，Vol.47Issue(12)：1766-1770,5.DOI:10.11675/j.issn.0253-4304.2025.12.11
荆防当归补血汤联合非奈利酮治疗2型糖尿病肾病患者的临床疗效及对患者尿微量白蛋白、尿转铁蛋白水平的影响
Clinical efficacy of Jingfang Danggui Buxue Decoction combined with finerenone for the treatment of patients with type 2 diabetic nephropathy and its effects on patients'microalbuminuria and urinary transferrin levels
摘要
Abstract
Objective To investigate the clinical efficacy of Jingfang Danggui Buxue Decoction combined with finerenone for the treatment of patients with type 2 diabetic nephropathy(T2DN)and its effects on patients'microalbuminuria(mALB)and urinary transferrin(UTF)levels.Methods A total of 78 patients with T2DN were divided into control group or observation group,with 39 cases in each group.The control group received finerenone for treatment,while the observation group received Jingfang Danggui Buxue Decoction combined with finerenone for treatment.Both groups were treated for 3 months.Post-treatment clinical efficacy,occurrence status of adverse reactions during treatment,and pre-and 3-month post-treatment renal function with respect to blood urea nitrogen(BUN),mALB,UTF levels,blood glucose levels in terms of fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPBG),HbA1c,and immune function(IgG,IgA,IgM levels)were compared between the two groups.Results After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of BUN,mALB,FPG,2hPBG,and HbA1c in both groups were lower than those before treatment,while the levels of UTF,IgG,and IgA were higher than those before treatment;furthermore,the obsearvation group exhibited a higher level of IgM as compared with before treatment.The levels of BUN,mALB,FPG,2hPBG,and HbA1c in the observation group were lower than those in the control group,and the levels of UTF,IgG,IgA,and IgM were higher than those in the control group(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups during treatment(P>0.05).Conclusion The clinical efficacy of Jingfang Danggui Buxue Decoction combined with finerenone in treating T2DN patients is superior to finerenone alone.It can effectively improve renal function,blood glucose levels,and immune function in T2DN patients,exerting good safety.关键词
2型糖尿病肾病/荆防当归补血汤/非奈利酮/肾功能/血糖/免疫功能Key words
Type 2 diabetic nephropathy/Jingfang Danggui Buxue Decoction/Finerenone/Renal function/Blood glucose/Immune function分类
医药卫生引用本文复制引用
XU Yali,CHEN Peng,GU Xianghao,ZHOU Yun,JI Xuexue..荆防当归补血汤联合非奈利酮治疗2型糖尿病肾病患者的临床疗效及对患者尿微量白蛋白、尿转铁蛋白水平的影响[J].广西医学,2025,47(12):1766-1770,5.基金项目
江苏省自然科学基金(BK20201497) （BK20201497）
