广西医学2025，Vol.47Issue(12)：1805-1813,9.DOI:10.11675/j.issn.0253-4304.2025.12.17
中国儿童Toll样受体基因多态性与肠道病毒71型感染手足口病易感性和严重程度相关性的Meta分析
Correlation of Toll-like receptor gene polymorphisms with susceptibility and severity of enterovirus 71-infected hand-foot-mouth disease in Chinese children:a Meta-analysis
摘要
Abstract
Objective To systematically evaluate the correlation between Toll-like receptors(TLRs)gene polymorphisms and susceptibility and severity of enterovirus 71(EV71)-infected hand-foot-mouth disease(HFMD)in Chinese children.Methods Databases including PubMed,The Cochrane Library,Embase,Web of Science,China National Knowledge Infrastructure,China Biomedical Literature Service System Database,WanFang Data Knowledge Service Platform,and VIP were searched via computer to collect case-control studies on TLRs gene polymorphisms and EV71-infected HFMD in Chinese children from database inception to August 2025.After extracting relevant data and assessing literature quality,Meta-analysis was performed using RevMan 5.4 and Stata 15.1 software.Results A total of 5 studies on TLR3 gene polymorphisms and 5 studies on TLR7 gene polymorphisms were included.Meta-analysis results revealed that various genotypes at TLR3 rs3775290 and TLR7 rs179019 loci were not significantly correlated with susceptibility to EV71-infected HFMD(P>0.05).For TLR7 rs3853839 locus,C allele and GC genotype in female children were risk factors for EV71-infected HFMD(P<0.05).Various genotypes at TLR3 rs3775291,TLR3 rs5743303,TLR7 rs179009,and TLR7 rs179019 loci were not correlated with disease severity of EV71-infected HFMD(P>0.05).T allele of TLR3 rs3775290 locus would increase risk of severe disease of EV17-infected HFMD.For TLR7 rs179016 locus,female children with GC genotype had an increased risk of severe disease compared to those with GG genotype,while GG genotype was a protective factor against severe disease compared to GC+CC genotype(P<0.05).For TLR7 rs3853839 locus,C allele in male children was a risk factor for severe EV71-infected HFMD(P<0.05).Conclusion C/G alleles at TLR7 rs3853839 locus may be correlated with susceptibility of EV17-infected HFMD,T/C alleles of TLR3 rs3775290 locus,female children with C/G alleles at TLR7 rs1790196 locus,male children with C/G alleles at TLR7 rs3853839 locus may be correlated with severity of EV17-infected HFMD,whereas more evidence is needed to clarify the correlations of other gene loci.关键词
手足口病/肠道病毒71型/Toll样受体/基因多态性/Meta分析Key words
Hand-foot-mouth disease/Enterovirus 71/Toll-like receptor/Gene polymorphism/Meta-analysis分类
医药卫生引用本文复制引用
YANG Ruifeng,XU Hua,YANG Fen,CHEN Guoming,LAN Wanning,ZHENG Jiyuan,ZHANG Meng,LAN Jun,XU Qing,LI Danyun,SONG Tie..中国儿童Toll样受体基因多态性与肠道病毒71型感染手足口病易感性和严重程度相关性的Meta分析[J].广西医学,2025,47(12):1805-1813,9.基金项目
广东省中医药局科研项目(20195005) （20195005）
