光明中医2025，Vol.40Issue(22)：4892-4895,4.DOI:10.3969/j.issn.1003-8914.2025.22.003
基于肺热叶焦理论探讨DM/PM-ILD的临床特征
Investigation on the Clinical Characteristics of DM/PM-ILD Based on the Theory of Lung Heat with Leaf Scorching
摘要
Abstract
Objective To explore clinical characteristics of dermatomyositis/polymyositis(PM/DM)complicated with interstitial lung disease(ILD)based on the theory of"lung heat with leaf scorching".Methods A retrospective analysis was conducted on 561 eligible patients with PM/DM who were treated at Shandong Provincial Hospital of Traditional Chinese Medicine and Qianfoshan Hospital from January 2020 to December 2024.These patients were divided into the ILD group(423 cases)and the non-ILD group(138 cases).The clinical characteristics and traditional Chinese medicine syndrome types of the two groups were compared.Results Compared with the non-ILD group,the ILD group had a higher positive rate of fever,myalgia/muscle weakness,arthralgia,rash,mechanic's hands,"complete triad",erythrocyte sedimentation rate(ESR),ferritin(FER),antinuclear antibody(ANA),anti-Ro52 antibody,anti-MDA5 antibody,and anti-ARS antibody.In contrast,the ILD group showed a lower positive rate of anti-TIF-1γ antibody,anti-Mi-2 antibody,anti-NXP2 antibody,and anti-SAE antibody,as well as decreased levels of creatine kinase(CK),creatine kinase-MB(CK-MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(αHBDH),total lung capacity(TLC),vital capacity(VC),forced vital capacity(FEV1),diffusing capacity of the lung for carbon monoxide(DLCO),and percentage of predicted diffusing capacity of the lung for carbon monoxide(DLCO%).All these differences were statistically significant(P<0.05).Conclusion Patients in the ILD group were characterized by prominent systemic hyperinflammatory manifestations,including fever,myalgia/muscle weakness,arthralgia,rash,"complete triad",mechanic's hands,as well as elevated positive rates of ESR,FER,ANA,anti-Ro52 antibody,anti-MDA5 antibody,and anti-ARS antibody.This is consistent with the core pathogenesis of the theory of"lung heat with leaf scorching",which features blazing heat-toxin,consumption of body fluids,and inadequate nourishment of the skin,muscles,and the five zang-organs.关键词
肌痹/皮肌炎/间质性肺疾病/肺热叶焦/中医证型Key words
musle bi-disease/dermatomyositis/interstitial lung disease/lung heat with leaf scorching/traditional Chinese medicine syndrome分类
医药卫生引用本文复制引用
CAO Jiaojiao,YANG Jianguo,FAN Bing..基于肺热叶焦理论探讨DM/PM-ILD的临床特征[J].光明中医,2025,40(22):4892-4895,4.基金项目
山东省医药卫生科技项目(No.202303111446) （No.202303111446）
