中医学报2026，Vol.41Issue(1)：25-32,8.DOI:10.16368/j.issn.1674-8999.2026.01.005
中医药治疗颈动脉粥样硬化斑块的临床研究证据图分析
Clinical Research Evidence Map Analysis of Traditional Chinese Medicine Treatment for Carotid Atherosclerotic Plaques
摘要
Abstract
Objective:This study aims to systematically review and evaluate the quality of clinical research on the treatment of carotid atherosclerotic plaques with traditional Chinese medicine(TCM)using evidence mapping.Methods:Eight Chinese and English databas-es,commonly used guideline databases,and guideline-related websites were searched.The search period ranged from database incep-tion to February 20,2025.Two researchers independently conducted screening,data extraction,and quality assessment,presenting the distribution and quality of clinical evidence using text combined with charts.Results:A total of 1 019 articles were included,comprising 997 clinical studies,20 systematic reviews/meta-analyses,and 2 guidelines/consensus documents.In recent years,the overall number of publications on this disease has shown a declining trend.Among clinical studies,43.03%focused on comorbid conditions associated with carotid atherosclerosis,and 324 studies(32.49%)mentioned the TCM syndrome types of the included patients,with phlegm-sta-sis intermingled syndrome being the most frequently observed.The sample sizes of clinical studies mostly ranged from 60 to 300 cases,and the intervention duration mostly ranged from 8 to 32 weeks.In Traditional Chinese Medicine(TCM)interventions,Tongxinluo Cap-sule,Banxia Baizhu Tianma Decoction and Shenqi Roumai Mixture are the most commonly used Chinese patent medicines,classic for-mulas,and self-devised formulas.Control measures mainly involved statins.Outcome indicators primarily included clinical efficacy,Crouse score,carotid intima-media thickness(cIMT),and plaque area.Regarding the methodological design of randomized controlled trials(RCTs),379 studies(40.53%)clearly mentioned the method of random sequence generation,12 studies(1.28%)mentioned allocation concealment,and28 studies(2.99%)mentioned blinding.In the methodological assessment of systematic reviews/meta-analyses,AMSTAR 2 scores were generally low.Conclusion:TCM has certain advantages in treating carotid atherosclerotic plaques,and the number of studies is substantial.However,the quality of studies is relatively low,with noticeable deficiencies in syndrome differenti-ation-based treatment plans and efficacy indicators,and methodological design flaws exist.In the future,more high-quality RCTs con-ducted under the guidance of TCM theory are needed to improve the level of evidence.关键词
颈动脉粥样硬化斑块/中医药/临床研究/证据图/随机对照试验/系统评价/方法学Key words
carotid atherosclerotic plaque/traditional Chinese medicine/clinical research/evidence map/randomized controlled trial/systematic review/methodology分类
医药卫生引用本文复制引用
YANG Yuhan,TONG Tong,ZUO Wenxi,WANG Qingqing,WANG Zeqi,YAO Kuiwu..中医药治疗颈动脉粥样硬化斑块的临床研究证据图分析[J].中医学报,2026,41(1):25-32,8.基金项目
癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项项目(四大慢病重大专项)(2024ZD0528300,2024ZD0528304) （四大慢病重大专项）
中国中医科学院眼科医院中央高水平中医医院项目(GSP2-02) （GSP2-02）
