中医学报2026，Vol.41Issue(1)：48-57,10.DOI:10.16368/j.issn.1674-8999.2026.01.008
基于双向两样本孟德尔随机化研究探讨"肺胃相关"理论的现代内涵
Modern Interpretation of"Lung-Stomach Correlation"Theory Based on Bidirectional Two-Sample Mendelian Randomization Study
摘要
Abstract
Objective To explore the causal relationship between respiratory and digestive diseases based on Mendelian randomization(MR)research,and to explain the modern medical connotation of"Lung and Stomach correlation"theory.Methods Based on the data of genome-wide association studies(GWAS)and the bidirectional two-sample MR method,the causal relationship between 16 re-spiratory traits representing"Lung Qi reversal"and 3 digestive system diseases representing"Stomach Qi reversal"was evaluated by u-sing a two-way two-sample MR method as an instrumental variable.Results GERD was significantly associated with an increased risk of chronic obstructive pulmonary disease(OR:1.48,P=6.43×10-15),asthma(OR:1.49,P=5.71×10-26),pneumonia(OR:1.17,P=1.84×10-7),bacterial pneumonia(OR:1.18,P=1.04×10-4)and bronchitis(OR:1.24,P=2.53×10-16),and was as-sociated with a reduction in FEV1(OR:0.91,P=2.90×10-11)and decreased FVC(OR:0.89,P=6.48×10-16).Barrett's esoph-agus was suggestively associated with an increased risk of asthma(OR:1.08,P=1.37×10-3)and pulmonary embolism(OR:1.10,P=3.15×10-2).Hiatal hernia is suggestively associated with an increased risk of bacterial pneumonia(OR:1.25,P=2.78×10-2).Multiple sensitivity analysis confirmed the robustness of the results.Conclusion There is a causal relationship between respiratory disea-ses and digestive system diseases,and the theory of"Lung and Stomach correlation"is explained from the perspective of genetics,which provides new evidence for the prevention and treatment of lung diseases.关键词
肺胃相关/孟德尔随机化/呼吸系统疾病/消化系统疾病/肺胃同降/中医药Key words
Lung and Stomach correlation/Mendelian randomization/respiratory disease/digestive disorder/Lung Qi and Stomach Qi descending/Chinese medicine分类
医药卫生引用本文复制引用
WANG Qiao,LIU Yuan,ZHAO Zezheng,CUI Jiaqi,HE Xinyi,LI Jiawen,ZHAO Xinran,YANG Daowen..基于双向两样本孟德尔随机化研究探讨"肺胃相关"理论的现代内涵[J].中医学报,2026,41(1):48-57,10.基金项目
国家重点研发计划项目(2022YFC3500801) （2022YFC3500801）
兵团财政科技计划项目(2020AB027) （2020AB027）
