中医学报2026，Vol.41Issue(1)：63-67,5.DOI:10.16368/j.issn.1674-8999.2026.01.010
基于代谢重编程探讨糖尿病肾脏病气虚血瘀证实质
Pathogenesis Essence of Diabetic Kidney Disease with Qi deficiency and Blood Stasis Syndrome Based on Metabolic Reprogramming
摘要
Abstract
Diabetic kidney disease(DKD)is an important microvascular complication in patients with diabetes and may lead to renal failure.Metabolic reprogramming,characterized by a core imbalance of material and energy flow,includes mitochondrial dysfunction,in-creased glycolysis,and lipid metabolism abnormalities.Qi deficiency and blood stasis are key pathological mechanisms in DKD.Meta-bolic reprogramming runs throughout the entire pathological progression of DKD,playing a promoting role in its development,while the presence of DKD also accelerates the process of metabolic reprogramming.The method of tonifying Qi and activating blood to resolve stasis is an important treatment for DKD.By treating both the root and the branch,it improves mitochondrial function,regulates metabol-ic balance,inhibits oxidative stress,and enhances renal function.Remodeling metabolic reprogramming helps restore normal metabolic order,thereby slowing down or reversing the progression of DKD.关键词
糖尿病肾脏病/代谢重编程/气虚血瘀证/益气活血化瘀法Key words
diabetic kidney disease/metabolic reprogramming/Qi deficiency and blood stasis syndrome/method of tonifying Qi and acti-vating blood to resolve stasis分类
医药卫生引用本文复制引用
LI Molin,LIU Xiuping..基于代谢重编程探讨糖尿病肾脏病气虚血瘀证实质[J].中医学报,2026,41(1):63-67,5.基金项目
国家自然科学基金面上项目(81273706) （81273706）
