河南中医2026，Vol.46Issue(1)：35-40,6.DOI:10.16367/j.issn.1003-5028.2026.01.0006
柴胡加龙骨牡蛎汤加味治疗慢性萎缩性胃炎临床研究
Clinical Study on Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell in the Treatment of Chronic Atrophic Gastritis
摘要
Abstract
Objective:To observe the clinical efficacy of Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell on chronic atrophic gastritis(CAG).Methods:A total of 120 CAG patients were divided into the study group and the control group using the random number table method,with 60 cases in each group.The control group received Omeprazole Enteric-coated Capsules and Col-loidal Bismuth Pectin Capsules for oral administration.The study group received Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell in addition to the treatment given to the control group.The clinical efficacy,and changes in TCM syndrome scores,ser-um gastric function indicators[including Gastrin-17(G-17),Pepsinogen Ⅰ(PG Ⅰ),Pepsinogen Ⅱ(PG Ⅱ),Endothelin-1(ET-1)],levels of inflammatory factors[including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and C-reactive protein(CRP)],and histopathological scores of gastric mucosa before and after treatment were compared between the two groups.Results:After treatment,scores for epigastric burning,epigastric fullness and stuffiness,poor appetite,fatigue and lassitude,bitter taste and halitosis,as well as the total scores,were lower than those before treatment within each group.Furthermore,these scores were lower in the study group than in the control group,with all differences being statistically significant(P<0.05).The effective rate was91.67%in the study group and 78.33%in the control group,showing a statistically significant difference(P<0.05).After treatment,the levels of G-17,PG Ⅰ,and PG Ⅱ in the study group were(385.43±31.02)ng·L-1,(122.15±12.09)ng·L-1,and(25.62±3.26)ng·L-1,respectively,which were higher than those before treatment in the same group and higher than those in the control group after treat-ment(P<0.05).The levels of ET-1,CRP,IL-6,and TNF-αin the study group after treatment were(65.52±7.53)ng·L-1,which were lower than those before treatment in the same group and lower than those in the control group after treatment(P<0.05).All path-ological scores of gastric mucosal tissues in the two groups after treatment were lower than those before treatment within each group,and the scores in the study group were lower than those in the control group(P<0.05).Conclusion:Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell is effective in treating CAG,which can significantly improve clinical symptoms,gastric function in-dicators,inflammatory response,and the pathological state of gastric mucosa of the patients.关键词
慢性萎缩性胃炎/柴胡加龙骨牡蛎汤加味/奥美拉唑肠溶胶囊/胶体果胶铋胶囊/中西医结合疗法/《伤寒论》/张仲景分类
医药卫生引用本文复制引用
YUAN Shuaiqiang,HOU Liufa,WANG Fei,ZHAO Lei,LOU Jing..柴胡加龙骨牡蛎汤加味治疗慢性萎缩性胃炎临床研究[J].河南中医,2026,46(1):35-40,6.基金项目
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目{豫中医函[2021]8号} （仲景工程）
河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才第二批培养项目{豫卫中医函[2021]15号} （仲景工程）
