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Targeting lactic acidosis in the tumor microenvironment:Enhancing TACE efficacy in hepatocellular carcinoma

Shuyi Hao Hong Yao Haojie Yu Lijun Wang Tingdong Yu Hongping Xia Yong Zha

肝脏研究（英文）2025，Vol.9Issue(4)：273-285,13.

肝脏研究（英文）2025，Vol.9Issue(4)：273-285,13.DOI:10.1016/j.livres.2025.11.004

Targeting lactic acidosis in the tumor microenvironment:Enhancing TACE efficacy in hepatocellular carcinoma

Shuyi Hao ¹Hong Yao ²Haojie Yu ³Lijun Wang ⁴Tingdong Yu ⁴Hongping Xia ⁵Yong Zha⁴

作者信息

1. Department of Hepatobiliary Pancreatic Surgery,Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University,Peking University Cancer Hospital Yunnan,Kunming,Yunnan,China||Department of Biochemistry,Yong Loo Lin School of Medicine,National University of Singapore,Singapore
2. Department of Cancer Biotherapy Center,Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University,Peking University Cancer Hospital Yunnan,Kunming,Yunnan,China
3. Department of Biochemistry,Yong Loo Lin School of Medicine,National University of Singapore,Singapore
4. Department of Hepatobiliary Pancreatic Surgery,Yunnan Cancer Hospital,The Third Affiliated Hospital of Kunming Medical University,Peking University Cancer Hospital Yunnan,Kunming,Yunnan,China
5. Zhongda Hospital,School of Medicine & Advanced Institute for Life and Health,Southeast University,Nanjing,Jiangsu,China
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摘要

关键词

Hepatocellular carcinoma(HCC)/Transarterial chemoembolization(TACE)/Tumor microenvironment(TME)/Lactic acidosis/Alkalization therapies/Lactate acid inhibition/Nanoparticles

Key words

Hepatocellular carcinoma(HCC)/Transarterial chemoembolization(TACE)/Tumor microenvironment(TME)/Lactic acidosis/Alkalization therapies/Lactate acid inhibition/Nanoparticles

引用本文复制引用

Shuyi Hao,Hong Yao,Haojie Yu,Lijun Wang,Tingdong Yu,Hongping Xia,Yong Zha..Targeting lactic acidosis in the tumor microenvironment:Enhancing TACE efficacy in hepatocellular carcinoma[J].肝脏研究（英文）,2025,9(4):273-285,13.

基金项目

This project was funded by Yunnan Province Science and Technology Talents and Platform Plan Project(No.202305AF150067) （No.202305AF150067）

The scientific and technological innovation team building program of Yunnan Provincial Education Depart-ment(No.K1322149) （No.K1322149）

Yunnan Province Talent Support Program(No.CZ0096-901264) （No.CZ0096-901264）

Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2025ZD0551500,2023ZD0501500),and Start-up fund of Southeast University & the China Hepatitis Prevention and Treatment Foundation Wang Baoen Liver Fibrosis Research Fund(No.2025055). （No.2025ZD0551500,2023ZD0501500）

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