肝脏研究（英文）2025，Vol.9Issue(4)：298-312,15.DOI:10.1016/j.livres.2025.10.001
Cancer cachexia-related monocytic myeloid-derived suppressor cells impair T-cell negative selection and predict immune-related adverse events
Cancer cachexia-related monocytic myeloid-derived suppressor cells impair T-cell negative selection and predict immune-related adverse events
Li Wei 1Xing Li 2Ya-Qin Sun 3Jian-Hua Ren 4Ze-Xuan Huang 5Yuan Zhang 6Xiu-Qing Pang 7Xiao-Tong Lv 1Xiang-Yuan Wu 1Yan-Fang Xing8
作者信息
- 1. Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China||Guangdong Key Laboratory of Liver Disease Research,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 2. Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China||Department of Medical Examination Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 3. Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 4. Department of Articular Surgery,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 5. Guangdong Key Laboratory of Liver Disease Research,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 6. Department of Obstetrics,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 7. Guangdong Key Laboratory of Liver Disease Research,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China||Department of Infectious Diseases,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
- 8. Department of Nephrology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China
- 折叠
摘要
关键词
Cancer cachexia/Thymus involution/T-cell negative selection/Monocytic myeloid-derived suppressor/cells(M-MDSCs)/Immune-related adverse events(irAEs)/Anti-PD-1/L1 therapyKey words
Cancer cachexia/Thymus involution/T-cell negative selection/Monocytic myeloid-derived suppressor/cells(M-MDSCs)/Immune-related adverse events(irAEs)/Anti-PD-1/L1 therapy引用本文复制引用
Li Wei,Xing Li,Ya-Qin Sun,Jian-Hua Ren,Ze-Xuan Huang,Yuan Zhang,Xiu-Qing Pang,Xiao-Tong Lv,Xiang-Yuan Wu,Yan-Fang Xing..Cancer cachexia-related monocytic myeloid-derived suppressor cells impair T-cell negative selection and predict immune-related adverse events[J].肝脏研究（英文）,2025,9(4):298-312,15.基金项目
This study was supported by the National Natural Science Foundation of China(No.82170749),the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010465 and 2022A1515012659),Guangzhou Science and Technology Program Key Projects(No.2023B01J1007),and the Traditional Chinese Medicine Bureau of Guangdong Province,China(No.20241045). （No.82170749）
