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Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns

Chao Wang Jianqi Feng Rui Fang Li Wang Qiong Ke Mingming Fan Jianrong Liu Xiaolu Guo Zhipeng Tan Xueying Huang Zhuoran Li Xiaomei Liu Ye Zhang

肝脏研究（英文）2025，Vol.9Issue(4)：313-323,11.

肝脏研究（英文）2025，Vol.9Issue(4)：313-323,11.DOI:10.1016/j.livres.2025.04.006

Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns

Chao Wang ¹Jianqi Feng ²Rui Fang ²Li Wang ³Qiong Ke ¹Mingming Fan ⁴Jianrong Liu ³Xiaolu Guo ²Zhipeng Tan ¹Xueying Huang ¹Zhuoran Li ¹Xiaomei Liu ¹Ye Zhang¹

作者信息

1. Center for Stem Cell Biology and Tissue Engineering,Key Laboratory for Stem Cells and Tissue Engineering,Ministry of Education,Sun Yat-sen University,Guangzhou,Guangdong,China
2. Shenzhen Qianhai Shekou Free Trade Zone Hospital,Shenzhen,Guangdong,China
3. Department of Hepatic Surgery and Liver Transplantation Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
4. Center for Stem Cell Biology and Tissue Engineering,Key Laboratory for Stem Cells and Tissue Engineering,Ministry of Education,Sun Yat-sen University,Guangzhou,Guangdong,China||Department of Surgery Intensive Care Unit,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,China
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摘要

关键词

Gene therapy/Adeno-associated virus(AAV)/Isolated hepatic perfusion(IHP)/Liver zonation/Genetic liver disease

Key words

Gene therapy/Adeno-associated virus(AAV)/Isolated hepatic perfusion(IHP)/Liver zonation/Genetic liver disease

引用本文复制引用

Chao Wang,Jianqi Feng,Rui Fang,Li Wang,Qiong Ke,Mingming Fan,Jianrong Liu,Xiaolu Guo,Zhipeng Tan,Xueying Huang,Zhuoran Li,Xiaomei Liu,Ye Zhang..Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns[J].肝脏研究（英文）,2025,9(4):313-323,11.

基金项目

This work was founded by the National Key Research and Devel-opment Program of China(No.2022YFA1104100,2018YFA0801404,2017YFA0104304,and 2024YFA1107200),The National Natural Sci-ence Foundation of China(No.82171617 and 82471689),Guangdong Special Support Program(No.2019BT02Y276),Sanming Project of Medicine in Shenzhen Nanshan(No.SZSM202103012),and Shenzhen Nanshan District Science and Technology Program(No.NS2022023,NS2023012,NSZD2024048,and NSZD2024051). （No.2022YFA1104100,2018YFA0801404,2017YFA0104304,and 2024YFA1107200）

肝脏研究（英文）

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