四川大学学报（医学版）2025，Vol.56Issue(6)：1453-1458,6.DOI:10.12182/20251160302
免疫耐受的守护者:调节性T细胞
Guardians of Immune Tolerance:Regulatory T Cells
摘要
Abstract
Shimon Sakaguchi,a Japanese scientist,together with Mary E.Brunkow and Fred Ramsdell,American scientists,were jointly awarded the 2025 Nobel Prize in Physiology or Medicine for their pioneering discoveries in the field of peripheral immune tolerance.This review summarizes the Nobel Prize-winning research on immune tolerance and discusses the development,functions,and therapeutic applications of regulatory T cell(Treg)-based interventions.These seminal studies on immune tolerance underscore a central immunological concept—a healthy immune system relies not only on its robust capacity to eliminate pathogens and mutated cells,but also on the precise inhibitory(or"brake")and tolerance mechanisms.This concept will help deepen our understanding of key medical challenges such as autoimmune diseases,transplant rejection,and tumor immunity.It will spur the development of a series of therapeutic strategies targeting peripheral immune tolerance and Treg cells and advance research in precision immune regulation.关键词
诺贝尔奖/外周免疫耐受/调节性T细胞/综述Key words
Nobel Prize/Peripheral immune tolerance/Regulatory T cells/Review引用本文复制引用
MING Kang,ZHANG Huiyuan,HU Hongbo..免疫耐受的守护者:调节性T细胞[J].四川大学学报（医学版）,2025,56(6):1453-1458,6.基金项目
国家自然科学基金(No.82025002、No.32230036和No.92574203)资助 （No.82025002、No.32230036和No.92574203）
