四川大学学报（医学版）2025，Vol.56Issue(6)：1459-1466,8.DOI:10.12182/20251160301
靶向调节性T细胞重塑外周免疫耐受:研究进展与未来方向
Targeting Regulatory T Cells to Remodel Peripheral Immune Tolerance:Research Advances and Future Directions
摘要
Abstract
Regulatory T cells(Tregs)are the most important population of immune cells in maintaining peripheral immune tolerance in the body.Targeting Tregs to rebuild peripheral immune tolerance has shown broad potential for application in the treatment of various inflammatory diseases,such as autoimmune diseases,allergic disorders,graft-versus-host disease,and organ transplant rejection.However,substantial challenges remain in translating Treg-based therapies into clinical practice.In this review,we first summarize the discovery of Tregs and the principal mechanisms through which Tregs inhibit immune responses.Then,the research progress in polyclonal Treg-based therapy,antigen-specific Treg-based therapy,and low-dose interleukin-2(IL-2)therapy and the implementation status of clinical trials of Treg therapies were comprehensively summarized.Finally,four issues,including maintaining the stability of Tregs,preparing autoantigen-specific Tregs,such as chimeric antigen receptor(CAR)-Tregs and T-cell receptor(TCR)-Tregs,reshaping the inflammatory microenvironment of diseases,and minimizing the potential adverse effects of Treg therapies,were highlighted as the bottleneck problems in the clinical translation of Treg therapies and priority directions for future research.关键词
调节性T细胞治疗/免疫治疗/自身免疫性疾病/移植物抗宿主病/Foxp3/低剂量IL-2治疗/综述Key words
Regulatory T cell therapy/Immunotherapy/Autoimmune diseases/Graft-versus-host disease/Foxp3/Low-dose interleukin-2 therapy/Review引用本文复制引用
ZHANG Wei,LI Zhenhong,LIANG Hantian,CHENG Hao,ZHANG Dunfang..靶向调节性T细胞重塑外周免疫耐受:研究进展与未来方向[J].四川大学学报（医学版）,2025,56(6):1459-1466,8.基金项目
国家自然科学基金(No.82171829)、四川省国际科技创新合作项目(No.2025YFHZ0205)和四川大学华西医院学科卓越发展1·3·5工程项目(No.ZYYC25010)资助 （No.82171829）
