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首页|期刊导航|四川大学学报（医学版）|中国0～9月龄胃肠不适婴儿功能性胃肠病的患病率及影响因素:一项多中心横断面调查研究

中国0～9月龄胃肠不适婴儿功能性胃肠病的患病率及影响因素:一项多中心横断面调查研究

WANG Zhiling LI Nan LI Yan NI Jia XIE Xiaoli ZHANG Lan WANG Xiaoyan ZHANG Jie GUO Jingmin HU Zehua YU Wen JIA Xintong YANG Chunsong WANG Haiying YANG Fan MAO Meng HU Chijun WU Jieling HU Dandan ZHONG Yan CHEN Jinjin HU Yan LI Xiaoqin

四川大学学报（医学版）2025，Vol.56Issue(6)：1513-1520,8.
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四川大学学报（医学版）2025，Vol.56Issue(6)：1513-1520,8.DOI:10.12182/20251160505

中国0～9月龄胃肠不适婴儿功能性胃肠病的患病率及影响因素:一项多中心横断面调查研究

Prevalence and Influencing Factors of Functional Gastrointestinal Disorders Among Infants Aged 0 to 9 Months With Gastrointestinal Discomfort in China:A Multicenter Cross-Sectional Survey

WANG Zhiling 1LI Nan 2LI Yan 3NI Jia 4XIE Xiaoli 5ZHANG Lan 6WANG Xiaoyan 7ZHANG Jie 8GUO Jingmin 9HU Zehua 10YU Wen 11JIA Xintong 1YANG Chunsong 12WANG Haiying 13YANG Fan 14MAO Meng 14HU Chijun 15WU Jieling 16HU Dandan 17ZHONG Yan 18CHEN Jinjin 19HU Yan 20LI Xiaoqin21

作者信息

  • 1. Department of Pediatric Gastroenterology,West China Second University Hospital,Sichuan University,Chengdu 610041,China||Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China
  • 2. Tianjin Women and Children Health Center,Tianjin 300070,China
  • 3. Department of Child Health Care,the First Affiliated Hospital of Shandong First Medical University,Shandong Provincial Qianfoshan Hospital,Jinan 250014,China
  • 4. Department of Developmental Pediatrics,Shenyang Maternity and Child Health Care Hospital,Shenyang 110014,China
  • 5. Department of Pediatric Gastroenterology,Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610091,China
  • 6. Children Healthcare Center,Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China
  • 7. Department of Child Healthcare,Children's Hospital,Capital Institute of Pediatrics,Beijing 100020,China
  • 8. Child Health Division,Xi'an Children's Hospital,Xi'an 710043,China
  • 9. Department of Children Healthcare,Fujian Maternity and Child Health Hospital,College of Clinical Medicine for Obstetrics&Gynecology and Pediatrics,Fuzhou 350001,China
  • 10. Department of Pediatrics,Dongguan Binhai Bay Central Hospital,Dongguan 523900,China
  • 11. Department of Child Health,The International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030,China
  • 12. Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China||Department of Pharmacy/Evidence-based Pharmacy Center,West China Second University Hospital,Sichuan University,Chengdu 610041,China
  • 13. Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China||Institute of Drug Clinical Trials,West China Second University Hospital,Sichuan University,Chengdu 610041,China
  • 14. Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China||Department of Child Health Care,West China Second University Hospital,Sichuan University,Chengdu 610041,China
  • 15. Department of Child Gastroenterology,Maternity and Child Health Care Hospital of Hubei Province,Wuhan 430070,China
  • 16. Child Healthcare Department,Guangdong Women and Children's Hospital,Guangzhou 511442,China
  • 17. Department of Child Healthcare,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China
  • 18. Department of Children Care,Hunan Children's Hospital,Changsha 410007,China
  • 19. Child Health Care Medical Division,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China
  • 20. Department of Child Health Care,Children's Hospital of Chongqing Medical University,Chongqing 400014,China
  • 21. Gastroenterology Department,Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital Zhengzhou Children's Hospital,Zhengzhou 450018,China
  • 折叠

摘要

Abstract

Objective To determine the prevalence of functional gastrointestinal disorders(FGIDs)in infants aged 0-9 months with gastrointestinal(GI)discomfort in different cities in China,and to investigate the associated influencing factors.Methods A multicenter cross-sectional survey was conducted.The questionnaire was developed based on the Rome Ⅳ Diagnostic Questionnaire for FGIDs in Neonates and Toddlers and published literature.Data were collected from infants aged 0-9 months with GI discomfort at 17 hospitals across 14 cities in eastern,central,and western China.Information on family demographics,neonatal records,feeding history,types and frequency of GI symptoms was collected.Logistic regression was performed to explore factors associated with FGIDs.Results A total of 2 528 infants aged 0-9 months with GI discomfort were enrolled,with 1 315 males(52.02％)and 1 213 females(47.98％).Among the surveyed infants,72.55％were diagnosed with FGIDs,with no statistically significant difference in prevalence between male and female infants(P=0.397).Regurgitation,with a prevalence of 39.83％,was the most common FGID.The prevalence of regurgitation and colic in infants decreased with increasing age,while the prevalence of dyschezia and functional constipation increased with increasing age.The prevalence of a single symptom was 57.48％,and approximately 15％of infants presented with 2 or more symptoms.The proportion of those presenting with 2 or more symptoms was the highest in infants aged 0-3 months(22.02％),whereas infants aged 6 to 9 months predominantly presented with a single symptom(65.96％).Univariate logistic regression identified significant associations between FGIDs and the geographic region,parental educational attainment,monthly per capita household income,infant age in days,gestational age at birth,duration of exclusive breastfeeding,and probiotic use(all P<0.05).Logistic regression analysis results showed that residing in the western region(odds ratio[OR]=0.407,95％CI:0.324-0.510),probiotic use(OR=0.69,95％CI:0.560-0.847),gestational age at birth(OR=0.914,95％CI:0.837-0.998),and the duration of exclusive breastfeeding>4 months(OR=0.75,95％CI:0.595-0.946)were significant factors influencing the occurrence of FGIDs(all P<0.05).Conclusion FGIDs are highly prevalent among infants aged 0-9 months with gastrointestinal symptoms in China.Their occurrence is linked to geographic region,probiotic use,gestational age,and breastfeeding duration.Future studies should focus on whether improved feeding guidance and breastfeeding promotion can help prevent FGIDs.

关键词

功能性胃肠病/婴儿/患病率/影响因素/横断面研究

Key words

Functional gastrointestinal disorders/Infants/Prevalence/Influencing factors/Cross-sectional study

引用本文复制引用

WANG Zhiling,LI Nan,LI Yan,NI Jia,XIE Xiaoli,ZHANG Lan,WANG Xiaoyan,ZHANG Jie,GUO Jingmin,HU Zehua,YU Wen,JIA Xintong,YANG Chunsong,WANG Haiying,YANG Fan,MAO Meng,HU Chijun,WU Jieling,HU Dandan,ZHONG Yan,CHEN Jinjin,HU Yan,LI Xiaoqin..中国0～9月龄胃肠不适婴儿功能性胃肠病的患病率及影响因素:一项多中心横断面调查研究[J].四川大学学报（医学版）,2025,56(6):1513-1520,8.

基金项目

中华国际医学交流基金会基金(No.Z-2017-27-2001)资助 （No.Z-2017-27-2001）

四川大学学报（医学版）

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