实用心电与临床诊疗2025，Vol.34Issue(6)：817-823,封3,8.DOI:10.13308/j.issn.2097-5716.2025.06.007
叉头框蛋白Q1和E-钙黏蛋白在胃癌组织中的表达及其临床意义
Expression of forkhead box Q1 and E-cadherin proteins in gastric cancer tissues and their clinical significance
摘要
Abstract
Objective To investigate the difference in the expression of forkhead box Q1(FOXQ1)and epithelial-cadherin(E-cadherin)proteins in gastric cancer tissues and adjacent tissues,analyze their relationship with clinicopathological features,and evaluate their potential clinical effect in the development and progression of gastric cancer.Methods The protein expression levels of FOXQ1 and E-cadherin were detected in 50 cases of gastric cancer tissues and matched adjacent tissues using the EnVision immunohistochemical method.The correlations between their expression and clinicopathological parameters were analyzed,and the relationship between their expression levels in gastric cancer tissues was further assessed.Results Both FOXQ1 and E-cadherin were expressed in gastric cancer and adjacent tissues.FOXQ1 protein was primarily localized in the cytoplasm,while E-cadherin protein was mainly expressed on the cell membrane.The positive expression rate of FOXQ1 was significantly higher in gastric cancer tissues than that in adjacent tissues(P＜0.05),and its expression was associated with lymph node metastasis and TNM stage(both P＜0.05).In contrast,the positive expression rate of E-cadherin was significantly lower in gastric cancer tissues than that in adjacent tissues(P＜0.01),and its expression correlated with the degree of tumor differentiation,depth of invasion,lymph node metastasis and TNM stage(all P＜0.05).A negative correlation was observed between FOXQ1 and E-cadherin expression in gastric cancer tissues(r=-0.301,P＜0.05).Conclusion The expression of both FOXQ1 and E-cadherin is closely associated with lymph node metastasis and TNM stage in gastric cancer.They may jointly participate in the invasion and metastasis processes of gastric cancer,suggesting their potential as therapeutic targets for advanced gastric cancer.关键词
叉头框蛋白Q1/E-钙黏蛋白/胃癌/上皮-间质转化/预后/淋巴结转移Key words
forkhead box Q1/epithelial-cadherin/gastric cancer/epithelial-mesenchymal transition/prognosis/lymph node metastasis分类
医药卫生引用本文复制引用
JIANG Han,WEI Jiahui..叉头框蛋白Q1和E-钙黏蛋白在胃癌组织中的表达及其临床意义[J].实用心电与临床诊疗,2025,34(6):817-823,封3,8.基金项目
江苏省老年健康科研项目(LKM2022031) （LKM2022031）
