实用心电与临床诊疗2025，Vol.34Issue(6)：824-829,6.DOI:10.13308/j.issn.2097-5716.2025.06.008
钙化性主动脉瓣病变危险因素研究
Research on risk factors for calcific aortic valve disease
QIAN Duoduo 1JIANG Kun 1LIAN Xiaoqing 1CHEN Xiangxuan 1TAO Qin 1ZHANG Yuqing 1FANG Xu1
作者信息
- 1. Department of Cardiovascular Medicine,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing Jiangsu 211100,China
- 折叠
摘要
Abstract
Objective To investigate the risk factors associated with calcific aortic valve disease(CAVD),and to provide a basis for clinical guidance and intervention.Methods A retrospective analysis was conducted on 184 patients diagnosed with CAVD by echocardiography.Clinical data and information on comorbidities were collected,and 217 subjects with normal aortic valve morphology were selected as a control group.Multivariate Logistic regression analysis was used to identify independent risk factors and related predisposing factors for CAVD.Results Advanced age,coronary heart disease,heart failure,renal insufficiency,or cerebral infarction were associated with a higher risk of CAVD.Among these,advanced age and renal insufficiency were independent risk factors for CAVD.Analysis of laboratory indicators suggested that lipoprotein(a)may be an independent risk factor for CAVD,and monitoring this indicator could help identify high-risk populations.Conclusion The occurrence of CAVD is closely related to advanced age and renal insufficiency,and elevated lipoprotein(a)may also be involved in its pathogenesis.关键词
钙化性主动脉瓣病变/主动脉瓣狭窄/脂蛋白(a)/瓣膜间质细胞/钙化性瓣膜病变Key words
calcific aortic valve disease/aortic stenosis/lipoprotein(a)/valve interstitial cell/calcific valvular disease分类
医药卫生引用本文复制引用
QIAN Duoduo,JIANG Kun,LIAN Xiaoqing,CHEN Xiangxuan,TAO Qin,ZHANG Yuqing,FANG Xu..钙化性主动脉瓣病变危险因素研究[J].实用心电与临床诊疗,2025,34(6):824-829,6.
