XIONG Yu 1ZHANG Zaiyong 1LI Jinglong 1TONG Yuwei 1LU Huan1
作者信息
- 1. @@@1.Department of Electrocardiogram,2.Department of Cardiology,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou Guangdong 510440,China
- 折叠
摘要
Abstract
Objective To investigate the prevalence and influencing factors of electrocardiogram(ECG)abnormalities in patients with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS).Methods A total of 680 HIV/AIDS patients were enrolled in this study.All patients underwent ECG examination,and the incidence of abnormalities was recorded.Based on the ECG results,patients were categorized into an abnormal group(n=455)and a normal group(n=225).Univariate and multivariate Logistic regression analyses were employed to identify independent risk factors for ECG abnormalities.Results Among the 680 patients,ECG abnormalities were detected in 455 cases,yielding an abnormality rate of 66.91％.Univariate Logistic regression analysis revealed that the two groups showed statistically significant differences in smoking history,pulmonary infection,CD4+T-cell count,CD8+T-cell count,antiretroviral therapy regimen,and the duration of highly active antiretroviral therapy(HAART)(all P＜0.01).Multivariate Logistic regression analysis further confirmed that smoking history,co-existing pulmonary infection,CD4+T-cell count＜200 cells/μL,CD8+T-cell count＜500 cells/μL,receiving HAART,and a HAART duration of ≥2 years were independent risk factors for ECG abnormalities.Conclusion The incidence of ECG abnormalities is high among HIV/AIDS patients,and is influenced by various factors,including immune status,co-infections and treatment-related factors.Clinically,it is essential to urge patients to quit smoking strictly,actively manage inflammatory conditions(such as pulmonary infection),initiate standardized antiretroviral therapy as early as possible,and strengthen regular ECG monitoring to improve their prognosis.关键词
人类免疫缺陷病毒/获得性免疫缺陷综合征/心电图/危险因素Key words
human immunodeficiency virus/acquired immune deficiency syndrome/electrocardiogram/risk factor分类
医药卫生
