昆明医科大学学报2025，Vol.46Issue(12)：1-8,8.DOI:10.12259/j.issn.2095-610X.S20251201
噬菌体联合抗生素疗法的协同作用机制及应用进展
Synergistic Mechanisms and Applications of Phage-antibiotic Combination Therapy
摘要
Abstract
The overuse of antibiotics has led to a rapid increase of antibiotic-resistant bacteria,making bacterial infections difficult to control effectively and posing a serious threat to human health.As antibiotic resistance problems become increasingly severe and the development of new antibiotics lags,finding more effective treatment strategies has become an urgent need in global public health.Bacteriophages,as a potential therapeutic option,have attracted increasing attention in recent years;however,bacteriophages have limitations such as a narrow host range and lysogeny.Synergistic effects between bacteriophages and antibiotics enhance bacteriophage lytic activity,reduce antibiotic dosage,significantly lower the risk of resistance development,and demonstrate superior antimicrobial efficacy.This review summarizes the mechanisms and research progress of bacteriophage-antibiotic synergy,aiming to further advance research and clinical application of combined bacteriophage-antibiotic therapy and provide new solutions to address the problem of antibiotic resistance.关键词
噬菌体/抗生素/联合疗法/耐药/协同作用Key words
Bacteriophage/Antibiotic/Combination therapy/Resistance/Synergistic effects分类
医药卫生引用本文复制引用
LI Xuelin,YANG Xiaoyan,HAN Zehua,CHEN Yuliang,XU Xingyuan,ZHANG Chunyan,XIANG Yingying..噬菌体联合抗生素疗法的协同作用机制及应用进展[J].昆明医科大学学报,2025,46(12):1-8,8.基金项目
国家自然科学基金(82360189) （82360189）
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202301AY070001-105) （202301AY070001-105）
云南省科技厅基础研究专项(202301AT070483) （202301AT070483）
云南省高层次卫生健康技术人才培养专项(D2024005) （D2024005）
