昆明医科大学学报2025，Vol.46Issue(12)：84-91,8.DOI:10.12259/j.issn.2095-610X.S20251210
卵巢癌患者血清sCD276、HE4水平及与患者术后复发的相关性
Serum sCD276 and HE4 Levels in Ovarian Cancer Patients and Their Correlation with Postoperative Recurrence
摘要
Abstract
Objective To investigate and analyze the correlation between serum soluble CD276(sCD276)and human epididymis protein 4(HE4)levels in ovarian cancer patients and postoperative recurrence.Methods A retrospective study enrolled 52 ovarian cancer patients treated at the Affiliated Hospital of Shandong Second Medical University from February 2022 to April 2023 as the study group.Additionally,50 normal healthy subjects examined during the same period were selected as the control group.Serum levels of sCD276 and HE4 were compared,and the correlation between serum sCD276 and HE4 levels and pathological characteristics of ovarian cancer patients was determined.Patients underwent one-year postoperative follow-up and were stratified into a recurrence group(n=12)a nd non-recurrence group(n=40)based on recurrence status during follow-up.Serum sCD276 and HE4 levels were compared between the two groups.Cox regression analysis was employed to identify high-risk factors for postoperative recurrence.Receiver operating characteristic(ROC)curves were constructed to analyze the predictive value of sCD276 and HE4 for postoperative recurrence.Kaplan-Meier survival analysis was performed.Results Compared with the control group,serum sCD276 and HE4 levels were elevated in the study group.Compared with the non-recurrence group,the recurrence group showed elevated serum sCD276 and HE4 levels,as well as significant differences in tissue differentiation degree,lymph node metastasis,postoperative residual tumor diameter,carcinoembryonic antigen(CEA),regulatory T lymphocyte(Treg)ratio,folate receptor 1(FOLR1),and carbohydrate antigen 125(CA125)(P<0.05).Cox regression analysis identified tissue differentiation degree,lymph node metastasis,postoperative residual tumor diameter,CEA,Treg ratio,FOLR1,sCD276,and HE4 were all risk factors for postoperative recurrence in ovarian cancer.ROC curve analysis revealed that combined detection of sCD276 and HE4 had superior diagnostic efficacy compared with single-marker detection,with statistically significant differences(P<0.05).Kaplan-Meier survival analysis showed that patients with high levels of sCD276 and HE4 had higher mortality rates than those with low levels(P<0.05).Conclusion Serum sCD276 and HE4 levels are elevated in ovarian cancer patients and are associated with postoperative recurrence.关键词
卵巢癌/可溶性CD276/人附睾蛋白4/糖类抗原125叶酸结合受体1Key words
Ovarian cancer/Soluble CD276/Human epididymal protein 4/Recurre分类
医药卫生引用本文复制引用
XING Ruisheng,LIU Hua,GAO Li,FANG Xiaobai,ZHAO Lei..卵巢癌患者血清sCD276、HE4水平及与患者术后复发的相关性[J].昆明医科大学学报,2025,46(12):84-91,8.基金项目
黑龙江省博士后资助项目(LBH-Z22275) （LBH-Z22275）
